NCT01089218已完成4 期
The Impact of Antibiotic Prophylaxis on Incidence of Post-bronchoscopy Fever and Change of Serum Cytokines
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 241
- 主要终点
- The incidence of fever
研究概览
简要总结
Fever can develop after fiberoptic bronchoscopy (FB) in about 2.5 - 16 % of adult patients. We evaluated the impact of oral amoxicillin/clavulanate (AC) on incidence of postbronchoscopic fever and pneumonia.
详细描述
For the population being undergone with bronchoscopy, the clinical signs and procedural measures for complication of bronchoscopy and cytokines will be checked.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients (aged 18 years or older) who underwent FB
排除标准
- •concurrent treatment with antibiotics or systemic corticosteroid
研究组 & 干预措施
control
No Intervention
control without intervention
干预措施: control (Drug)
Amoxicillin/clavulanate
Active Comparator
干预措施: oral amoxicillin/clavulanate 1g (875/125mg) (Drug)
结局指标
主要结局
The incidence of fever
时间窗: 24 hr after bronchoscopy
time frame for body temperature 24hr before and after bronchoscopy every 4hrs
次要结局
- change of serum cytokines level(before bronchoscopy and 24hr after bronchoscopy)
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