Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and Kidney Uptake

Not Applicable

Completed

• Conditions: Ketoses, Metabolic
• Interventions: Radiation: Observational heart and kidney on siemens TEP scan

• Registration Number: NCT05238805
• Lead Sponsor: Université de Sherbrooke

Brief Summary

The objective of this study is to make a comparison between 11C-acetate and 11C-Acetoacetate heart and kidney metabolism

Detailed Description

Healthy people will have two positron emission tomography scan to perform. One, with a 11C-Acetate Tracer and the other with 11C-Acetoacetate. The results will allow to determine if both tracers are used in a similar way but the organs and see if the investigators can use the already validated analyse method for acetate to make acetoacetate analysis

Study Timeline

• Study First Submitted: 2022-01-04
• Study First Submitted QC: 2022-02-03
• Study First Posted: 2022-02-14
• Study Start: 2022-03-14
• Primary Completion: 2022-08-14
• Study Completion: 2022-08-14
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-16
• Last Update Posted: 2023-01-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Aged between 18 and 55
• BMI between 18,5 and 28
• Healthy
• Normal value for blood pressure

Exclusion Criteria

• Taking drugs that could influence metabolism
• Diabetes or prediabetes
• Pregnancy or lactation
• Participation in a intensive sport program
• Being on a ketogenic diet
• Any clinical abnomally in prescreen blood sample

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Observational heart and kidney metabolism	Observational heart and kidney on siemens TEP scan	Participants will have a PET scan with 11C-Acetate followed by a TEP Scan with 11C-Acetoacetate all in the same day.

Primary Outcome Measures

Name	Time	Method
Mean in left ventricule myocradial blood flow	30 minutes	Heart acetate metabolism measured by TEP scan
Mean in left ventricule myocardial blood flow	30 minutes	Heart acetoacetate metabolism measured by TEP scan
Mean in Kidney acetoacetate uptake	30 minutes	Kidney acetoacetate uptake measured by TEP scan.
Mean in Kidney acetate uptake	30 minutes	Kidney acetate uptake measured by TEP scan

Trial Locations

Locations (1)

Research Center on Aging; 🇨🇦 Sherbrooke, Quebec, Canada