Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis

Not Applicable

Terminated

• Conditions: Progressive Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting
• Interventions: Other: Neuropsychological assessment; Other: Neurologic consultation; Other: MRIs (with vasoreactivity testing)

• Registration Number: NCT02580669
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs and the Diffusion Tensor Imaging , and correlate these differences with Clinical disability and cognitive disorder results.

Detailed Description

The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs, and correlate these differences with Clinical disability and cognitive disorder results. The modification of the Diffusion Tensor Imaging are well known in these two groups, as well as their link with the occurrence of movement and cognitive disorder. The study of the vasoreactivity during MRI aims to confront our results to the available data sources.

Study Timeline

• Study Start: 2014-06-16
• Study First Submitted: 2015-09-25
• Study First Submitted QC: 2015-10-16
• Study First Posted: 2015-10-20
• Primary Completion: 2017-02-13
• Study Completion: 2017-02-13
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-14
• Last Update Posted: 2021-05-18

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Multiple Sclerosis, Relapsing-Remitting	Neurologic consultation	22 patients with Multiple Sclerosis, Relapsing-Remitting will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing)
Progressive Multiple Sclerosis	Neuropsychological assessment	22 patients with Progressive Multiple Sclerosis will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing)
Multiple Sclerosis, Relapsing-Remitting	Neuropsychological assessment	22 patients with Multiple Sclerosis, Relapsing-Remitting will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing)
Healthy volunteers (22 patients)	MRIs (with vasoreactivity testing)	22 healthy volunteers will be included and they get an Neuropsychological assessment and MRIs (with vasoreactivity testing)
Progressive Multiple Sclerosis	Neurologic consultation	22 patients with Progressive Multiple Sclerosis will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing)
Progressive Multiple Sclerosis	MRIs (with vasoreactivity testing)	22 patients with Progressive Multiple Sclerosis will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing)
Healthy volunteers (22 patients)	Neuropsychological assessment	22 healthy volunteers will be included and they get an Neuropsychological assessment and MRIs (with vasoreactivity testing)
Multiple Sclerosis, Relapsing-Remitting	MRIs (with vasoreactivity testing)	22 patients with Multiple Sclerosis, Relapsing-Remitting will be included and they get an Neuropsychological assessment, a Neurologic consultation and MRIs (with vasoreactivity testing)

Primary Outcome Measures

Name	Time	Method
Cerebral vasoreactivity measured by diffusion imaging MRI (quantitative variable) :parameter which allow us to estimate the organization of the white matter tracts	2 months

Secondary Outcome Measures

Name	Time	Method
Comparison of fonctional connective cards at Resting state	2 months	somatomotor network and default mode network
Cognitive disorders	2 months	Neuropsychological test results (quantitative and quantitative variable)

Trial Locations

Locations (1)

Hopital Gui de Chauliac -Service de Neurologie; 🇫🇷 Montpellier, France