Azelaic Acid Versus Hydroquinone in Melasma
- Registration Number
- NCT00927771
- Lead Sponsor
- Callender Center for Clinical Research
- Brief Summary
The purpose of this study is to compare the safety and effectiveness of Azelaic Acid Gel to Hydroquinone Cream in the treatment of melasma.
- Detailed Description
Melasma is a chronic condition in which dark areas appear on the forehead, cheeks, and upper lips. Hydroquinone is a skin lightener (or fade cream) and is one of the most commonly used medications for the treatment of melasma. Azelaic acid gel is currently used to treat acne and rosacea.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- must have stable moderate-severe epidermal or mixed melasma involving the face
- all races
- males and females
- persons taking birth control medication, hormone replacement therapy or any other hormone altering medication may participate only if they have not started or stopped the medication within the last 3 months
Exclusion Criteria
- if the person has only dermal melasma
- pregnancy, breastfeeding, a positive pregnancy test in the office or plans to become pregnant
- a known allergy or sensitivity ot azelaic acid or hydroquinone
- the use of photosensitizing medications (ex. tetracycline) within 3 months of the study.
- starting or stopping hormonal medication within 3 months
- chemical peels, microdermabrasion, or laser treatment within 6 months
- worsening or improving melasma
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Azelaic Acid azelaic acid gel - Hydroquinone hydroquinone cream -
- Primary Outcome Measures
Name Time Method Improvement of melasma 6 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Callender Center for Clinical Research
🇺🇸Mitchellville, Maryland, United States