Vitamin D Status After Single Oral Dose of Cholecalciferol in Low Fat Meal Compared to High-fat Meal
- Conditions
- Deficiency, Vitamin D
- Interventions
- Dietary Supplement: colecalciferol
- Registration Number
- NCT00968734
- Lead Sponsor
- Federal University of Rio Grande do Sul
- Brief Summary
The purpose of this study is to evaluate the absorption of dietary supplement of vitamin D3 (cholecalciferol), through the variation of 25 (OH) D levels, as the fat content of the meal associated with the administration of the supplement.
- Detailed Description
Clinical randomized controlled double-blind study with healthy subjects to investigate the effect of low and high fat of meal on absorption of vitamin D supplement. Participants were randomly in two groups according to sex and BMI.
In the same date, each group of participants received a meal and dietary supplement of vitamin D3 (cholecalciferol) after the first blood sample and a urine sample. Others samples were collected in the seventh and fourteenth day after intake the supplement.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Residents of the hospital clinics of Porto Alegre
- Don't drink milk
- Obesity
- Malnutrition
- Liver disease
- Kidney disease or diabetes
- Use of dietary supplements containing calcium and vitamin D
- Medications
- Anticonvulsants
- Barbiturates, or steroids.
- Having performed a journey the last four months to locations near the Earth's equatorial plane, due to sun exposure that may have occurred during this period, or vacations planned during the study period.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Hight fat meal colecalciferol - Low fat meal colecalciferol -
- Primary Outcome Measures
Name Time Method Serum Level of Vitamin D3 14 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital de Clínicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande do Sul, Brazil