Dual-task Exercise in People With Cognitive Impairment

Not Applicable

Active, not recruiting

• Conditions: Dementia; Mild Cognitive Impairment; Older Adults
• Interventions: Other: Dual-task exercise traning

• Registration Number: NCT06389812
• Lead Sponsor: Loughborough University

Brief Summary

The purpose of this study is to explore how performing two exercise-based tasks simultaneously (dual-task exercise) affects the neurovascular and cognitive responses of people with cognitive impairment, which is a growing concern globally. Specifically, the study will examine how motor-cognitive dual-task exercises, such as using elastic resistance bands combined with visual perception training, including eye movement exercises, can immediately improve outcomes such as Brain-derived neurotrophic factor (BDNF) levels, cerebral blood flow, cognitive function, and mobility. BDNF is a special chemical in our brain that helps with the connections between brain cells. Participants will be asked to complete a single 30-minute exercise session and undergo assessments before and after the intervention. Participants with cognitive impairment will be initially assessed using Mini-Mental State Examination (MMSE) which is a 30-point questionnaire used extensively in clinical and research settings to measure cognitive impairment. Any score of 24 or more (out of 30) indicates normal cognition. Below this, scores can indicate severe (≤9 points), moderate (10-18 points), or mild (19-23 points) cognitive impairment. Participants with lower MMSE scores (\<10) will be removed from the study.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-08-30
• Status Verified: 2024-04
• Study First Submitted: 2024-04-25
• Study First Submitted QC: 2024-04-25
• Last Update Submitted: 2024-04-25
• Study First Posted: 2024-04-29
• Last Update Posted: 2024-04-29
• Primary Completion: 2024-04-30
• Study Completion: 2024-09-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age >65 (PwD or cognitively impaired older adults) (ICD-10)
• People with and without cognitive impairment (MMSE score 13-30)
• Subjects must be able to exercise at a moderate intensity level (see exclusion criteria)
• Subject must be willing and able to provide a blood sample

Exclusion Criteria

• • Subjects with other neurological disease (stroke, Parkinson's, or multiple sclerosis)

  • Significant current orthopaedic (fractures, hemiplegia, pain, arthritis etc.), cardiovascular and pulmonary conditions (arrhythmias, uncontrolled hypertension, acute bronchitis, cardiac insufficiency etc.) that would limit the ability to perform cardio-respiratory fitness assessment, tasks or exercise
  • Psychiatric conditions (depression, anxiety disorder, etc.) and a history of severe psychiatric disorders (schizoaffective/bipolar disorders, or schizophrenia)
  • Severe vision/hearing impairments that cannot be corrected with aids
  • Unable to comprehend questionnaire material study procedures

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dual-task group	Dual-task exercise traning	. The motor-cognitive dual-task group will be additionally asked to do horizontal eye movements by watching a TV screen and following a duck moving from side to side (bilateral condition) while performing strengthening exercises. only one session 30 mins.
eye movement exercise group	Dual-task exercise traning	asked to do horizontal eye movements by watching a TV screen and following a duck moving from side to side (bilateral condition) while performing strengthening exercises. The duck moves successively between left and right banks of a river at a rate of 500 ms (Brunyé et al., 2009) which was previously found to improve cognitive function. only one session 30 mins.

Primary Outcome Measures

Name	Time	Method
BDNF serum level	before and immediately after treatment	Blood samples will be drawn from the antecubital vein by venepuncture in dry vacuum tubes immediately before the beginning of the exercise training and within 5 min from the termination of the exercise session. Serum will be obtained by the centrifugation of blood (2,000 g for 10 min, 4°C) and then all serum samples will be stored at -80°C until analysis (Máderová et al., 2019).

Secondary Outcome Measures

Name	Time	Method
Visual screening	before and immediately after treatment	visual processing speed

Trial Locations

Locations (1)

Loughborough University; 🇬🇧 Loughborough, Leicestershire, United Kingdom