A randomized control trial comparing high flow oxygen therapy with low level pressure support during spontaneous breathing trial

Not Applicable

Recruiting

• Conditions: pressure support ventilation; ready to wean; high flow oxygen therapy; mechanical ventilation; weaning; - mechanically ventilated patients&#45

• Registration Number: TCTR20190703002
• Lead Sponsor: Faculty of Medicine Siriraj Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-03
• Study Completion: 2020-08-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 330

Inclusion Criteria

1. Age 18-90 years
2. On mechanical ventilation for at least 24 hours
3. Ready to wean by the following criteria
- FiO2 < 0.5
- Positive end expiratory pressure < 8 cmH2O
- PaO2/FiO2 > 200 หรือ SpO2 > 92%
- Respiratory rate < 30/min
- Stable hemodynamic (without or receiving norepinephrine less than 0.05 mcg/kg/min)
- Well cooperate
4. Agree to participate

Exclusion Criteria

1. Unstable hemodynamics: at least one of the following criteria
- SBP > 180 or < 90 mmHg
- DBP > 120 or < 60 mmHg
- Heart rate > 140 or < 60/min
- Presence of shock or poor tissue perfusion
2. Severe acid-base disturbance: pH < 7.3 or > 7.55
3. Pregnant women
4. Trachostomized patients

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of SBT success 30 minutes SBT

Secondary Outcome Measures

Name	Time	Method
Extubation rate 48 hours extubation,28-day mortality 28 days mortality,Blood pressure 30 minutes non-invasive blood pressure measurement,Heart rate 30 minutes heart rate,Oxygen saturation 30 minutes pulse oximetry