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Clinical Trials/NCT05780476
NCT05780476
Recruiting
Not Applicable

A Novel Virtual Reality Intervention for Caregivers of People With Dementia.

IRCCS Centro San Giovanni di Dio Fatebenefratelli1 site in 1 country100 target enrollmentOctober 27, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Caregiver Burden
Sponsor
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Enrollment
100
Locations
1
Primary Endpoint
Change in anxiety
Status
Recruiting
Last Updated
3 years ago

Overview

Brief Summary

This clinical trial aims to explore if a virtual reality experience increases the beneficial effect of psychoeducational programs in informal caregivers of people with mild-to-moderate Alzheimer's disease. This study will test changes in psychological distress and neural activity in brain systems that regulate stress and empathic care.

Participants will be randomized into two arms: the control group will participate in an online psychoeducational intervention, while the experimental group will participate in the psychoeducational intervention combined with virtual reality.

Registry
clinicaltrials.gov
Start Date
October 27, 2022
End Date
August 1, 2025
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Responsible Party
Principal Investigator
Principal Investigator

Cristina Festari, PhD

Researcher

IRCCS Centro San Giovanni di Dio Fatebenefratelli

Eligibility Criteria

Inclusion Criteria

  • Being an unpaid informal caregiver (CG; i.e., family members or friends) living with or caring for a person with Alzheimer's Disease (AD) for at least 4 hours a day for at least six months before enrolment;
  • Caring for a person with a diagnosis of AD at prodromal or mild stage (i.e., Mini-Mental State Examination score:18-24) and still living at home.

Exclusion Criteria

  • Receiving daily assistance for more than 10 hours from formal CGs;
  • Being formal CGs (i.e., nurse or another paid figure);
  • Being informal CGs of i) persons with moderate-to-severe AD, or ii) persons with non-AD diseases;
  • Not having or being able to use a device connected to internet (e.g., smartphones or PC).
  • Having received psychotherapeutic o psychological support, or having already participated to psychoeducational programs.
  • Only a family member for person with dementia is accepted.
  • Exclusion Criteria for experimental group (Psychoeducation + VR):
  • Medical history of epilepsy.
  • Exclusion Criteria for subsample of caregivers assess with MRI:
  • Metal implants, artificial prostheses, pace-makers, prosthetic heart valves;

Outcomes

Primary Outcomes

Change in anxiety

Time Frame: Baseline (pre-intervention); Post-intervention (up to a week post-intervention).

State Trait Anxiety Inventory - STAI-Y

Change in distress of care after intervention

Time Frame: Baseline (pre-intervention); Post-intervention (up to a week post-intervention).

Zarit Burden interview - ZBI

Secondary Outcomes

  • Change in sense of competence(Baseline (pre-intervention); Post-intervention (up to a week post-intervention).)
  • Modulation of neural activity in brain systems regulating empathy(Baseline (pre-intervention); Post-intervention (up to a week post-intervention).)
  • Change in empathy(Baseline (pre-intervention); Post-intervention (up to a week post-intervention).)

Study Sites (1)

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