Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery
Not Applicable
Completed
- Conditions
- Tooth, Impacted
- Registration Number
- NCT02942108
- Lead Sponsor
- University of Belgrade
- Brief Summary
The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- bilaterally symmetrically impacted lower third molars
Exclusion Criteria
- presence of intraoral infection
- chronic orofacial pain
- pregnancy/ lactation
- heavy tobacco smokers
- alcohol/ drug abuse
- allergic reaction to medicaments used
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method SOD activity in alveolar bone specimen immediately after surgery Activity of enzyme superoxide dismutase in bone specimens obtained during lower third molar surgery
MMP-9 level in alveolar bone specimen immediately after surgery VEGF levels in alveolar bone specimen immediately after surgery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
School of Dental Medicine, University of Belgrade
🇷🇸Belgrade, Serbia
School of Dental Medicine, University of Belgrade🇷🇸Belgrade, Serbia