Piezoelectric Vibrations and Tissue, Cellular and Molecular Mechanisms of Oral Wound Healing After Third Molar Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- SOD activity in alveolar bone specimen
研究概览
简要总结
The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •bilaterally symmetrically impacted lower third molars
排除标准
- •presence of intraoral infection
- •chronic orofacial pain
- •pregnancy/ lactation
- •heavy tobacco smokers
- •alcohol/ drug abuse
- •allergic reaction to medicaments used
研究组 & 干预措施
healthy, conventional surgery
Surgical bone removal by conventional rotary burs in healthy patients during third molar surgery
干预措施: conventional surgery (Procedure)
healthy, piezo surgery
Surgical bone removal by piezoelectric vibrations in healthy patients during third molar surgery
干预措施: piezo surgery (Procedure)
结局指标
主要结局
SOD activity in alveolar bone specimen
时间窗: immediately after surgery
Activity of enzyme superoxide dismutase in bone specimens obtained during lower third molar surgery
VEGF levels in alveolar bone specimen
时间窗: immediately after surgery
MMP-9 level in alveolar bone specimen
时间窗: immediately after surgery
次要结局
未报告次要终点
研究者
Bozidar Brkovic, DDS, MSc, PhD, Professor
DDS, PhD, Associate Professor
University of Belgrade