EUCTR2006-004927-12-GB进行中（未招募）1 期
A double-blind randomised placebo controlled study of cotrimoxazole in the treatment of advanced pulmonary fibrosis - cotrimoazole in advanced fibrotic lung disease
St Helier Hospital NHS Trust0 个研究点目标入组 140 人开始时间: 2010年1月13日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Male & female 40-80 yrs . History and investigationssupport a diagnosis of pulmonary fibrosis. Ct scan but biopsy not essential.
- •Patients maybe established on prednisolone (1-30mg) or have ceased prednisolone due to lack of effect.Patients must show oxygen desaturation on exercise to below 90% on shuttle walking test and score MRC dyspnoea score 3 or above
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Secondary causes of lung fibrosis, orsignificant COPD,Asthma, sarciod that could invalidate the study outcome measures. Those on lontterm oxygen, Heart disease and those unable to perform the shuttle walking test. Pregnant women, cotrimoxazole allergy, untreated B12 & folate deficiency Renal failure with creatinine above 180. Known G-6-PD deficiency
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