Oxytocin Receptor Expression in Pregnancy: When Does it Turn on
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Oxytocin receptor expression
研究概览
简要总结
This study aims to determine when during gestation oxytocin receptor (OXTR) expression increases in the myometrium, which will contribute new insight to the management of obstetric hemorrhage and our understanding of normal and abnormal labor.
详细描述
In this descriptive study, we will obtain myometrial tissue samples by core needle biopsy under ultrasound guidance in anesthetized women immediately following surgical abortion and from controls, all of whom are undergoing a separate planned obstetric/gynecologic surgery. Tissue studies will be performed on these biopsy samples to examine oxytocin receptor expression and function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women age 18-50
- •Gestational age 14-26 weeks; or 6-13 weeks, 37-42 weeks, or non-pregnant (controls)
- •Undergoing another planned surgical procedure with anesthesia (suction D&C, D&E, gravid hysterectomy, cesarean section, or laparoscopic tubal ligation)
- •Able to give informed consent in English or Spanish
排除标准
- •To optimize biopsy safety, we will exclude patients with anticipated difficult cases, that have additional risks of hemorrhage, or those with features that limit ultrasound visualization.
- •Increased risk of hemorrhage:
- •Anemia (Hgb < 9)
- •Anticoagulation, bleeding disorder, or coagulopathy
- •Multiple gestation
- •Infection or sepsis
- •For ultrasound-guided procedures:
- •Obese, BMI ≥ 40
- •History of ≥2 cesarean sections
- •Large fibroids or uterine anomalies obstructing view
- •Other poor visualization
- •Thin myometrium < 1cm
结局指标
主要结局
Oxytocin receptor expression
时间窗: 30 minutes
Measure of oxytocin receptor expression. Perform quantitative RT-PCR on mRNA extracted from biopsy samples obtained from subjects at the end of their procedure (within 30 minutes).
次要结局
- Function of myometrial oxytocin receptor(30 minutes)
研究者
Jessica Reid
Instructor
Oregon Health and Science University