To know if the mouth wash prepared from certain herbal products is effective and safe to treat the gingivitis

Not yet recruiting

Conditions: Other specified bacterial diseases,

Registration Number: CTRI/2024/01/061413

Lead Sponsor: DR ZADC AMU ALIGARH

Brief Summary: Periodontal diseases have adestructive effect on the supporting tooth tissues. The mildest form of thesediseases is gingivitis which is characterized by bleeding, plaque

formation  andgum inflammation .Several lines of evidence haveshown that elimination of microbial dental plaque biofilm prevents gingivitis. In addition to mechanical oral

hygiene approaches, there is a need for additional measures to controlbacterial plaque formation by using antimicrobial dentifrices or anti-plaque

mouthwashes. Chlorhexidine, a bisguanideis considered benchmark of antimicrobial rinses due to its high substantivityand wide range of activity. Chlorhexidine is not a

â€˜Miraculous solutionâ€™ as it hasdefinite  after effects like taste alteration, mucosal irritation, dry mouth,tooth discoloration, cytotoxic effect.Based on the ill-effects of

chlorhexidine, World Health Organization admonishedresearchers to probe the potential of herbs and plant extracts. Hence, finding newer antiplaqueand

antimicrobial agents with a natural origin is important to increasetreatment compliance and reduce adverse effects upon long-term application. In dentistry,

Herbal concentrateswere used to lessen  inflammation, prevent dental caries, to heal gingivitis& periodontitis, and as antimicrobials & antioxidants. The

natural products used in thisstudy were Indian gooseberry (Emblica Officinalis), cinnamon(Cinnamomum Cassia), HydratedMagnesium silicate(silicate of

magnesia), Black seed(Nigella Sativa),Eucalyptus oil(Eucalyptus Globulus) .Theefficacy of all the substances were proven individually. The combined effect of

the substances was not studied previously . Thus the aim of the study was toevaluate the clinical safety and efficacy of polyherbal mouthwash containing Indian

gooseberry, Cinnamon, Hydrated magnesium silicate, black seed And Eucalyptus oil against commerciallyavailable chlorhexidine mouthwash.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 156

Inclusion Criteria

APPARENTLY HEALTHY INDIVIDUALS WITH PRESENCE OF ATLEAST 20 NATURAL TEETH DIAGNOSIS OF GINGIVITIS-DENTAL BIOFILM INDUCED.

Exclusion Criteria

1)PREGNANCY AND LACTATION 2)DECOMPENSATED SYSTEMIC DISEASE 3)DEGENERATIVE BONE DISEASE 4)SJOGREN SYNDROME 5)ADVANCED PERIODONTAL OR ORTHODONTIC DISEASE 6)HISTORY OF ORAL PROPHYLAXIS WITHIN 6 MONTHS 7)HISTORY OF TAKING ANTIBIOTICS,ANTICOAGULANT,IMMUNOSUPPRESSIVE,ANTI-INFLAMMATORY MEDICATION OR USING ANTI-BACTERIAL MOUTH RINSES FOR PAST 6 MONTHS.
8)SMOKING,DRUG AND ALCOHOL ABUSE.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)DECREASE IN SALIVARY CRP LEVEL	three months
2)DECREASE IN GINGIVAL INDEX,GINGIVAL BLEEDING INDEX,PLAQUE INDEX	three months

Secondary Outcome Measures

Name	Time	Method
effectiveness of polyherbal mouth wash	three months

Trial Locations

Locations (1): DR. Ziauddin Ahmad Dental College
🇮🇳
Aligarh, UTTAR PRADESH, India
DR. Ziauddin Ahmad Dental College
🇮🇳Aligarh, UTTAR PRADESH, India
RASHMIAZIM
Principal investigator
9045618522
rashmi.azim@gmail.com