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Clinical Trials/ISRCTN66534807
ISRCTN66534807
Completed
Not Applicable

A randomised clinical trial of Azithromycin versus Ofloxacin in the treatment of adults with uncomplicated typhoid fever at Mahosot Hospital, Vientiane, Lao People's Democratic Republic (PDR)

niversity of Oxford (UK)0 sites88 target enrollmentDecember 7, 2005
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ConditionsTyphoid feverInfections and Infestations

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Typhoid fever
Sponsor
niversity of Oxford (UK)
Enrollment
88
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
December 7, 2005
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
niversity of Oxford (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Adult (more than or equal to 15 years, either sex) non\-pregnant patients with suspected or blood culture proven typhoid
  • •2\. Fever more than 37\.5 °C
  • •3\. Informed written consent to the study
  • •4\. Able to stay in hospital for seven days
  • •5\. Able to take oral medication
  • •6\. Body weight more than 40 kg
  • •7\. Likely to be able to complete six months follow up
  • •8\. None of the exclusion criteria

Exclusion Criteria

  • •1\. Known hypersensitivity to ofloxacin or azithromycin
  • •2\. Administration of chloramphenicol, co\-trimoxazole, ampicillin, azithromycin or a fluoroquinolone during the previous week
  • •3\. Pregnancy or breast feeding
  • •4\. Contraindications to ofloxacin or azithromycin
  • •5\. Evidence for severe typhoid

Outcomes

Primary Outcomes

Not specified

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