Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea. The Role of Body Fat Distribution in the Prevalence of Obstructive Sleep Apnea.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 87
- 试验地点
- 1
- 主要终点
- Apnea hypopnea index
研究概览
简要总结
Comparison of the prevalence of obstructive sleep apnea (OSA), measured by polysomnography in normal weight patients with central obesity by body mass index (BMI) and waist hip ratio (WHR), with normal weight patients without central obesity by BMI and WHR.
Evaluation of arterial stiffness and vascular age in normal weight patients with central obesity and in normal weight patients without central obesity.
Determination of the exercise response characteristics in OSA patients.
详细描述
Body composition (the distribution of adipose tissue) appears to be a risk factor for the prevalence of obstructive form of sleep apnea. The investigators expect a higher prevalence of this serious sleep pathology in normal weight patients with central obesity than in normal weight patient without central obesity. In normal weight patients with central obesity also endothelial dysfunctions, abnormal exercise response to dynamic load and abnormal circadian patterns of blood pressure and heart rate can be expected. There are theoretical assumptions for this hypothesis but relevant studies on sufficiently large samples of patients have not been done. The investigators will also compare the lipid profile in normal weight patients with central obesity with those of normal weight patients without central obesity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •acute infection
- •known diagnosis of chronic renal or cardiac failure
- •taking drugs that affect sleep (stimulants, hypnotics, antidepressants, antipsychotics, anxiolytics, antihistamines, corticosteroids, theophylline, anti-parkinsonic drugs, anticonvulsants, morphine-type analgetics)
结局指标
主要结局
Apnea hypopnea index
时间窗: Through study completion, an average of 1 year
Apnea hypopnea index will be measured in both groups
次要结局
- Response on ergo-spirometry test(Through study completion, an average of 1 year)
- Cardio Ankle Vascular Index (CAVI)(Through study completion, an average of 1 year)
- Ambulatory 24-hour blood pressure measurement (ABPM)(Through study completion, an average of 1 year)