Revascularization of Young Immature Permenant Teeth Using Different Types of Intra Canal Medication

Not Applicable

Not yet recruiting

• Conditions: Traumatic Teeth; Necrotic Teeth
• Interventions: Drug: Triple Antibiotic Paste; Drug: Glycyrrhizin; Drug: Grape Seed Extract

• Registration Number: NCT07236567
• Lead Sponsor: Al-Azhar University

Brief Summary

Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial

Detailed Description

Digital count of e.faecalis before and after application of different type of intra canal medication

Study Timeline

• Status Verified: 2025-11
• Study First Submitted: 2025-11-15
• Study First Submitted QC: 2025-11-15
• Last Update Submitted: 2025-11-15
• Study First Posted: 2025-11-19
• Last Update Posted: 2025-11-19
• Study Start: 2025-12-01
• Primary Completion: 2027-10-01
• Study Completion: 2027-11-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• Healthy children aged from 7-13 years old.
• Patient with necrotic pulp.
• Open apex.

Exclusion Criteria

.

• Teeth with root fractures.
• Presence of root resorptions.
• Presence of periodontal pockets.
• Developmental anomalies.
• Tooth with class III mobility

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group a	Triple Antibiotic Paste	Revascularization with triple antibiotic paste as intracanal medication
Group c	Glycyrrhizin	Revascularization with glycyrrhizin as intracanal medication
Group b	Grape Seed Extract	Revascularization with grape seed extract as intra canal medication

Primary Outcome Measures

Name	Time	Method
Digital count of e.faecalis	After One week of mediation application	Microbiological evaluation The number of E. faecalis will be digitally counted.
Clinical evaluation success will be assessed using following criteria of success according to scoring system Absence of : - Pain, - Soft tissue swelling - soft tissue inflammation - Sinus tract - tenderness to percussion - tooth mobility	After one week of mediation application	Clincal success will be assessed using following criteria of success according to clinical scoring system; Absence of : * Pain,; * Soft tissue swelling; * soft tissue inflammation; * Sinus tract; * tenderness to percussion; * tooth mobility. Clinical score Clinical symptom Definition; 1. asymptomatic Pathology: absent Normal functioning Mobility (physiological) ≤1mm; 2. Slight discomfort, short-lived Pathology: questionable Percussion sensitivity Gingival inflammation (due to poor oral hygiene) Mobility (physiological) \> 1mm, but \<2mm; 3. Minor discomfort, short-lived Pathology: initial changes present Gingival swelling (not due to poor oral hygiene) Mobility \> 2mm, but \< 3 mm; 4. Major discomfort, long-lived extract immediately Pathology: late changes present Spontaneous pain Gingival swelling (not due to poor oral hygiene) Periodontal pocket formation(exudate) Sinus tract present Mobility ≥ 3mm Premature tooth loss, due to pathology

Secondary Outcome Measures

Name	Time	Method
Radiographic evaluation	After tweleve month	After tweleve months take periapical radiograph to detection normal lamina dura and increase in root thikness and length. Criteria for success according to radiographic scoring system

Trial Locations

Locations (1)

Al-Azhar University faculty of dental medicine; 🇪🇬 Cairo, Egypt