Effects of a Dietary Fiber on Human Gut Microbiota, Bioactive Metabolites and Blood Glucose Control
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Focus of the Study is on Gut Health
- Sponsor
- Ingredion Incorporated
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Metabolizable energy
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of the study is to examine how a dietary fiber affects metabolism in healthy overweight and obese adults. The fiber will be added to foods that participants will consume for two, three-week periods. The fiber will be given in two doses -- 15 g per day during one period, and 30 g per day in the other. In another three-week period, they will consume the same foods, but with no fiber added. Major outcomes will include fermentability of the fiber, as assessed by measurement of breath hydrogen, as well as shifts in fecal bacteria. The caloric value of the fiber will be determined and metabolic measures related to blood glucose control and inflammation will also be taken.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Body mass index from 25 to 35 kg/m
- •Willing to consume study foods and comply with dietary exclusions and specimen collection
Exclusion Criteria
- •Pregnancy
- •Gastrointestinal disease
- •Regular use of pre- or probiotics
- •Recent use of antibiotics
- •High intake of dietary fiber
Outcomes
Primary Outcomes
Metabolizable energy
Time Frame: 7 days, 3 times
Urine and feces will be collected for 7 days at the end of each treatment period to allow for assessment of metabolizable energy
Fermentability
Time Frame: One, eight-hr day, three times
Breath hydrogen will be measured hourly, over eight hours at the end of each treatment period
Secondary Outcomes
- Blood glucose(For eight hours, three times)
- Fecal microbiota(2 days, three times, and 7 days, three times)