Effects of a Dietary Fiber on Human Gut Microbiota, Bioactive Metabolites and Blood Glucose Control
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Metabolizable energy
研究概览
简要总结
The purpose of the study is to examine how a dietary fiber affects metabolism in healthy overweight and obese adults. The fiber will be added to foods that participants will consume for two, three-week periods. The fiber will be given in two doses -- 15 g per day during one period, and 30 g per day in the other. In another three-week period, they will consume the same foods, but with no fiber added. Major outcomes will include fermentability of the fiber, as assessed by measurement of breath hydrogen, as well as shifts in fecal bacteria. The caloric value of the fiber will be determined and metabolic measures related to blood glucose control and inflammation will also be taken.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body mass index from 25 to 35 kg/m
- •Willing to consume study foods and comply with dietary exclusions and specimen collection
排除标准
- •Pregnancy
- •Gastrointestinal disease
- •Regular use of pre- or probiotics
- •Recent use of antibiotics
- •High intake of dietary fiber
结局指标
主要结局
Metabolizable energy
时间窗: 7 days, 3 times
Urine and feces will be collected for 7 days at the end of each treatment period to allow for assessment of metabolizable energy
Fermentability
时间窗: One, eight-hr day, three times
Breath hydrogen will be measured hourly, over eight hours at the end of each treatment period
次要结局
- Blood glucose(For eight hours, three times)
- Fecal microbiota(2 days, three times, and 7 days, three times)