Evaluation of MG53 (TRIM72) Levels in Women With Polycystic Ovary Syndrome: An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Serum MG53 level
研究概览
简要总结
Purpose of the Study:
This study is being conducted to examine a protein called MG53 (also known as TRIM72) in women with polycystic ovary syndrome (PCOS). MG53 is involved in cell membrane repair and may play a role in insulin resistance, which is common in PCOS.
Study Procedures:
Women between 18 and 45 years of age will be invited to participate. The study population will include both women diagnosed with PCOS and healthy controls. A single blood sample (approximately 5 mL) will be collected from each participant. MG53 levels will be measured using an ELISA laboratory assay.
Significance of the Study:
Analysis of MG53 levels in relation to hormonal and metabolic markers may help determine whether MG53 is associated with insulin resistance and other characteristics of PCOS.
详细描述
Background:
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age and is often associated with insulin resistance and metabolic disturbances. MG53 (TRIM72) is a membrane repair protein that has been shown in some experimental studies to affect insulin signaling and glucose metabolism.
Rationale:
Because insulin resistance is a key feature of PCOS, investigating MG53 levels in women with PCOS may provide new insights into the pathophysiology of the syndrome. Understanding whether MG53 is elevated and how it correlates with metabolic and hormonal parameters could lead to new diagnostic or therapeutic approaches in the future.
Study Design:
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female participants aged 18 to 45 years
- •Diagnosed with polycystic ovary syndrome (PCOS) according to Rotterdam criteria or healthy controls without PCOS
- •Able and willing to provide informed consent
排除标准
- •Currently pregnant
- •Presence of chronic systemic disease
- •Use of metformin or any hormonal treatment
结局指标
主要结局
Serum MG53 level
时间窗: Baseline (single time point at enrollment)
Serum MG53 levels measured by ELISA in women with PCOS and healthy controls. Time Frame: At the time of blood draw (single measurement at enrollment)
次要结局
- Correlation between MG53 levels and BMI(At the time of blood draw (single measurement at enrollment))
- Correlation between MG53 levels and hormonal parameters(At the time of blood draw (single measurement at enrollment))
- Correlation between MG53 levels and lipid parameters(At the time of blood draw (single measurement at enrollment))
- Correlation between MG53 levels and insulin resistance (HOMA-IR)(At the time of blood draw (single measurement at enrollment))
研究者
Havva Betül Bacak
M.D
Gaziosmanpasa Research and Education Hospital