Action-effect Anticipation in Patients With Parkinson's Disease : A Study of the Sensory Attenuation Marker.

Terminated

• Conditions: Parkinson Disease
• Interventions: Behavioral: behavioral observation

• Registration Number: NCT02894333
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

The ideomotor theory of action control is considered to be central to the understanding of human voluntary action. According to the ideomotor theory, an action is represented in terms of its desired sensory effects and actions are selected by internally activating these effect representations. Recent imagery and behavioral studies showed that this anticipated representation of action-effects triggered a "sensory attenuation", meaning a decrease of perceptive performances or a decrease of sensory event-related potentials (ERP) for an expected event. Thus, the sensory attenuation constitutes a relevant behavioral tool to investigate sensory anticipation impairment in patients with Parkinson's disease. In a behavioral paradigm, patients and matched control participants have to perform a perceptive task on predicted visual action-effects mixed with mispredicted visual action effects. Performances should be better in mispredicted visual action effects for control participants only.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-12
• Study First Submitted: 2016-09-05
• Study First Submitted QC: 2016-09-05
• Study First Posted: 2016-09-09
• Primary Completion: 2018-09
• Study Completion: 2019-09
• Status Verified: 2019-12
• Last Update Submitted: 2019-12-20
• Last Update Posted: 2019-12-23

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 1

Inclusion Criteria

• Parkinson's disease
• Normal or corrected vision

Exclusion Criteria

• Other pathology or neurological or psychiatric history
• Known pregnancy or breastfeeding
• Absence of affiliation to the French Social Security
• Person under legal protection
• Patient's opposition to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with Parkinson's disease	behavioral observation	-

Primary Outcome Measures

Name	Time	Method
median score	baseline	scores measured with the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS)

Trial Locations

Locations (2)

Fondation Adolphe de Rothschild; 🇫🇷 Paris, France

Fondation Ophtalmologique Adolphe de Rothschild; 🇫🇷 Paris, France