NCT04057326Unknown不适用
A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Study to Evaluate the Safety and Efficacy of Oryz-Aspergillus Enzyme and Pancreatin Tablet in Improving Malnutrition in Patients With Cirrhosis
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 132
- 主要终点
- 1. Change in nutritional status by Mid-Arm Muscle Circumference (MAMC) evaluation, the unit of MAMC is centimeter(cm).
研究概览
简要总结
The investigation is a randomized, double-blind, placebo involved and multi-center clinical trial. All subjects are assigned to 2 groups, including Oryz-Aspergillus Enzyme and Pancreatin tablet group (treatment group) and the placebo group (control group). Treatment group includes 99 subjects, while control group includes 33 subjects. They receive investigational drug 2 tablets/times, tid, p.o. for 180 days.
详细描述
- A total of 132 subjects with cirrhosis were divided into 3 subgroups by Child-Pugh score, which were Child-pugh Class A, B, and C, respectively. Each subgroup includes 44 subjects, which were randomly assigned to the Oryz-Aspergillus Enzyme and Pancreatin tablet group (treatment group) and the placebo group (control group) in a ratio of 3: 1 (33: 11).
- Patients who have signed the Informed Consent Form and are eligible for the entry criteria will be randomly assigned to either the Oryz-Aspergillus Enzyme and Pancreatin tablet group or the placebo group. No matter which group the subjects is assigned, he/she would receive treatment drugs through oral administration for 180 days, during which the participant will not take any investigational drug.
- The differences in nutritional status between treatment group and control group will be compared in 90 and 180 days by MAMC and SGA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The age is range from 18 to 70 years old.
- •Sex is not limited.
- •Confirmed cirrhosis (pathologic or radiological rationale) with a mid-upper arm muscle circumference (MAMC) < 90% of the standard value.
- •The subject or his family (guardians) agreed to participate in the study and signed the informed consent form.
- •Note: MAMC formula: mid-arm muscle circumference (cm) = mid-arm circumference (cm) - 3.14 × triceps skinfoldthickness. Standard values: 25.3 cm for adult males and 23.2 cm for adult females.
排除标准
- •Subjects will be excluded from the study if they meet any of the following criteria:
- •Pregnant, lactating women or women who do not exclude the possibility of pregnancy;
- •Total serum bilirubin ≥ 5 times the upper limit of normal;
- •Serum creatinine ≥ 1.2 times the upper limit of normal;
- •Prothrombin time ≥ 18 seconds;
- •Those who have an allergy to Oryz-Aspergillus Enzyme and Pancreatin Tablet and their related ingredients;
- •Subjects who are not able to eat orally for any reason;
- •Subjects with a history of previous intestinal obstruction;
- •Subjects with acute abdominal pain within 2 months prior to the start of the study;
- •Subjects with electrolyte (sodium, potassium, chlorine) disorders that cannot be corrected prior to the start of the study, if electrolyte (sodium, potassium, chlorine) disorders have occurred, have been corrected and stabilized for more than 1 month prior to the start of the study;
- •Subjects with prior hepatic encephalitic stage II or higher;
- •History of refractory ascites with moderate or higher ascites within 2 weeks prior to the start of the study;
- •Subjects with symptoms of gastrointestinal bleeding such as melena and hematemesis within 2 weeks prior to the start of the study;
- •Those who have used antibiotics within 2 weeks prior to the start of the study;
- •Subjects who experienced other conditions that could affect the study: Subjects who had acquired or primary, secondary immune system conditions (except primary autoimmune liver disease) such as major cardiopulmonary disease, diabetes mellitus, tumors, HIV infection, and other conditions that required long-term hormonal therapy;
- •Substance abuse: Alcohol abuse (80 g/day) for < 6 months with a history of intravenous or/and inhaled drugs (drugs) in the last two years;
- •Subjects with chronic viral hepatitis B/C who started and/or adjusted their antiviral regimen within 6 months prior to the start of the study;
- •Subjects with a history of surgery within 6 months prior to the start of the study;
- •Subjects with autoimmune liver disease who started or adjusted their regimen within 6 months prior to the start of the study (i.e., subjects who have started treatment for the aetiology with no change in treatment regimen and drug dose in the new addition of ursodeoxycholic acid or hormones, immunosuppressants, etc., in June)
- •Those who participated in other drug trials within 3 months prior to the start of the study;
- •Any subject who is considered by the investigator to be unable to participate in the study.
研究组 & 干预措施
Oryz-Aspergillus Enzyme and Pancreatin Tablet Arm
Active Comparator
Oryz-Aspergillus Enzyme and Pancreatin Tablet ,2 tablets/time, 3 times daily. Study drug will be administered orally.
干预措施: Oryz-Aspergillus Enzyme and Pancreatin Tablet (Drug)
Placebo Arm
Placebo Comparator
Placebo,2 tablets/time, 3 timesdaily. Study drug will be administered orally.
干预措施: Placebo (Drug)
结局指标
主要结局
1. Change in nutritional status by Mid-Arm Muscle Circumference (MAMC) evaluation, the unit of MAMC is centimeter(cm).
时间窗: 180 days
The change in nutritional status of subjects at 180 days was evaluated by MAMC. MAMC, as a marker of lean muscle mass, is calculated using the standard formula: MAMC = MAC-(3.14 x TSF thickness). MAC: mid-arm circumference TSF : triceps skinfold thickness
2. Change in nutritional status by Subjective Global Assessment (SGA) evaluation.
时间窗: 180 days
The change in nutritional status of subjects at 180 days was evaluated by SGA Form. The nutritional status of the subjects was improved if any of the index reached the "effective" standard.
次要结局
未报告次要终点
研究者
相似试验
Unknown
不适用
Phase ⅡStudy of Tyroserleutide for Injection in Hepatocellular Carcinoma(HCC) PatientsHepatocellular CarcinomaNCT00644020Shenzhen Kangzhe Pharmaceutical Co., Ltd.100
Unknown
4 期
Efficacy and Safety of Yuxuebi Tablet in Treating Night Pain of Ankylosing Spondylitis (AS).Ankylosing SpondylitisNCT04934059China Resources Sanjiu Medical & Pharmaceutical Co., Ltd.60
已完成
2 期
Evaluate the Efficacy and Safety of D-2570 in Participants With Moderate-to-Severe Plaque PsoriasisPlaque PsoriasisNCT06278350InventisBio Co., Ltd161
招募中
1 期
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Uterine Blood Mesenchymal Stem Cells Injection for the Treatment of Severe Pneumonia Caused by VirusesSevere Viral Pneumonia(Not Include COVID-19)NCT06693362Ruijin Hospital60
Unknown
3 期
Study of Tyroserleutide for Injection in Hepatocellular Carcinoma (HCC) PatientsHepatocellular,CarcinomaNCT01489566Shenzhen Kangzhe Pharmaceutical Co., Ltd.300