Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD

Phase 2

Completed

• Conditions: Electromyography; Temporomandibular Disorder; Myofascial Pain; Cannabis
• Interventions: Combination Product: Cannabis Cream; Combination Product: Placebo Cream

• Registration Number: NCT03994640
• Lead Sponsor: Medical University of Silesia

Brief Summary

Evaluation of myorelaxant effect of cannabis cream.compared to placebo cream in topical skin application in patients with TMD

Detailed Description

Cannabis sativa has a very wide application in various fields of medicine. In patients with temporomandibular disorder, especially with myofascial pain of masticatory muscles there is a special need to seek an effective pain therapy and muscle relaxing methods. Patients with TMD suffer from chronic pain and depression, cannabis topical skin application therapy seems promising in that field. Patients attending The Department of TMD in Zabrze, Polska were randomly divided into two groups: experimental and placebo. sEMG activity values were compared during 14 days therapy with cream. Positive results were obtained confirming the efficacy of the cannabis cream used in the study, compared to placebo.

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2018-10-01
• Study Completion: 2019-01-01
• Status Verified: 2019-06
• Study First Submitted: 2019-06-17
• Study First Submitted QC: 2019-06-20
• Last Update Submitted: 2019-06-20
• Study First Posted: 2019-06-21
• Last Update Posted: 2019-06-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cannabis cream	Cannabis Cream	Cannabis cream topical skin application in experimental group
Placebo cream	Placebo Cream	Placebo cream topical skin application in control group

Primary Outcome Measures

Name	Time	Method
Reduction of sEMG activity of masseter muscle	14 days	Reduction in masseter muscle electromyographic activity

Trial Locations

Locations (1)

Department of TMD Silesian Medical University; 🇵🇱 Zabrze, Poland