A New Era in the Treatment of Chronic Lateral Epicondylitis: Comparison of Targeted Biological Support Using a Hyaluronic Acid and Amino Acid Combination Versus Exercise Therapy: A Retrospective, Controlled Clinical Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Change in Pain Intensity (VAS)
Study Overview
Brief Summary
This retrospective, controlled clinical study aims to evaluate the effectiveness of a targeted biological support injection containing a hyaluronic acid and amino acid combination in patients with chronic lateral epicondylitis (tennis elbow). Medical records will be reviewed to compare outcomes between patients treated in routine clinical practice with a 3-dose injection regimen (weeks 0, 2, and 4) plus a home exercise program and those treated with a home exercise program alone. Key outcome measures include pain intensity (VAS), functional status (PRTEE), grip strength, and pressure pain threshold.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients aged between 18 and 70 years.
- •Patients diagnosed with Lateral Epicondylitis (LE).
- •Presence of symptoms persisting for 6 weeks or longer.
- •Patients who were treated with either a 3-dose protocol of Hyaluronic Acid + Amino Acid injection combined with a home exercise program, or a home exercise program alone.
Exclusion Criteria
- •History of rheumatic disease.
- •History of malignancy.
- •Presence of radiculopathy or neuropathy.
- •Presence of peripheral circulatory disorders.
- •Congenital or acquired upper extremity deformities.
- •History of coagulopathy or current use of warfarin therapy.
- •Presence of prosthesis, metal implant, or internal fixator in the elbow region.
Arms & Interventions
Intervention Group: HA+AA Injection + Home Exercise Program
Patients in this retrospective cohort were treated with a targeted biological support injection (Hyaluronic Acid and Amino Acid combination) administered at weeks 0, 2, and 4, in addition to the standardized home exercise program.
Intervention: Home Exercise Program (Behavioral)
Control Group: Home Exercise Program Only
Home exercise program without injection.
Intervention: Home Exercise Program (Behavioral)
Intervention Group: HA+AA Injection + Home Exercise Program
Patients in this retrospective cohort were treated with a targeted biological support injection (Hyaluronic Acid and Amino Acid combination) administered at weeks 0, 2, and 4, in addition to the standardized home exercise program.
Intervention: Hyaluronic Acid + Amino Acid Injection (Drug)
Outcomes
Primary Outcomes
Change in Pain Intensity (VAS)
Time Frame: Baseline, Week 4, and Month 3
Pain intensity will be measured using a 10-cm Visual Analog Scale (VAS).
Secondary Outcomes
- Change in Pressure Pain Threshold (Algometry)(Baseline, Week 4, and Month 3)
- Change in Functional Status (PRTEE Score)(Baseline, Week 4, and Month 3)
- Change in Grip Strength (Hand Dynamometer)(Baseline, Week 4, and Month 3)
Investigators
Serkan Polat
MD
Sivas State Hospital