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Clinical Trials/NCT04894539
NCT04894539
Completed
Not Applicable

Transcutaneous Electrical Nerve Stimulation as a Pain-relieving Approach in Labor Pain Control: a Randomized Double-blinded Controlled Pilot Study

Aalborg University1 site in 1 country12 target enrollmentAugust 1, 2019
ConditionsLabor Pain

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Labor Pain
Sponsor
Aalborg University
Enrollment
12
Locations
1
Primary Endpoint
Change in Visual Analog scale (VAS)
Status
Completed
Last Updated
4 years ago

Overview

Brief Summary

Transcutaneous electrical nerve stimulation (TENS) is a non-invasive electro-physical modality used for several pain conditions including labor pain control. Despite several years of research, there is still no agreement within the literature regarding the selection of TENS parameters. It is aimed to investigate two types of TENS frequencies (TENS1 alternating between 4 to 100 Hz and TENS2 alternating between 80 to 100 Hz) compared to sham-TENS.

Detailed Description

Midwives and the study investigator will ask parturients, who are admitted to the labor ward at Region Hospital Herning satisfying the inclusion and exclusion criteria, whether they are interested in attending the experimental session. The study will be conducted as soon as the subject is admitted at the labor ward. The study will only be conducted during early and active labor and not during the birth of the baby. The subject in this study includes the package of a parturient and her neonate (after birth) as we also obtain data about the neonate. Hereby, two consent forms will be obtained. As this study is a non-invasive study, it is decided to have at least the consent of one parent. The investigator will fill out a questionnaire about the parturient in cooperation with the subject and midwife, including screening questions related to inclusion and exclusion criteria before the experimental session starts. The study will last approximately one hour and will be conducted during laboring circumstances. KT (Kenoja Thuvarakan) will carry out the experiment, and she will be present in the delivery room during the whole session. The study includes several outcomes, including subjective and semi-objective pain measures. The primary outcome is VAS (0-10 cm scale), while secondary outcomes include PPT and satisfaction questionnaire (only at the end of the study). The subjects will be asked before, and immediately after the experimental exposure about the four outcomes (VAS and PPT). The subjects will be exposed to one of the two combinations of TENS stimulation (low and high alternating frequency), which will be compared to sham-TENS.

Registry
clinicaltrials.gov
Start Date
August 1, 2019
End Date
June 6, 2021
Last Updated
4 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Sponsor
Aalborg University
Responsible Party
Principal Investigator
Principal Investigator

Kenoja Thuvarakan

Principle Investigator

Aalborg University

Eligibility Criteria

Inclusion Criteria

  • Singleton pregnancy
  • Between ages 18-39 years
  • Vertex presentation
  • Speak, read and understand Danish
  • At term (37-42 weeks gestation age)

Exclusion Criteria

  • High-risk pregnancies (including risk factors: eclampsia, pre-eclampsia, diabetes, gestational diabetes, hypertension, and hypotension, intrauterine growth restriction, polyhydramnios, and oligohydramnios).
  • Pre-gestational body mass index above 40 kg/m2
  • Use of fetal-scalp electrode during the experiment
  • Use of pacemakers and other electronic implants
  • Severe arrhythmia
  • Present musculoskeletal/neurological illnesses
  • Chronic pain within last 6 months
  • Present medicated mental disorders
  • Dermatological disorders
  • Use of other long-acting pain relief

Outcomes

Primary Outcomes

Change in Visual Analog scale (VAS)

Time Frame: Baseline, 10 minutes post stimulation, 30 minutes post stimulation

10-cm pain intensity scale with 0 cm is no pain and 10 cm is unbearable pain. Decreased cm after baseline measurement indicates pain relief.

Change in Pain pressure threshold

Time Frame: Baseline, 10 minutes post stimulation, 30 minutes post stimulation

Pain sensitivity measurement also defined as the minimum pressure needed to evoke a pain response measured in kPa. Increased kPa after baseline measurement indicates pain relief.

Secondary Outcomes

  • Recommend TENS to others(Right after last measurements of VAS & PPT)
  • Satisfaction of TENS(Right after last measurements of VAS & PPT)
  • Experienced pain reduction(Right after last measurements of VAS & PPT)
  • Interest in the use of TENS again(Right after last measurements of VAS & PPT)

Study Sites (1)

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