An observational study of critically ill patients with severe acute respiratory distress syndrome.
Not Applicable
Completed
- Conditions
- Acute respiratory distress syndromeRespiratory - Other respiratory disorders / diseases
- Registration Number
- ACTRN12619000403134
- Lead Sponsor
- Rachael Parke
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Patients must meet all of the following inclusion criteria:
1.Age equal to or greater than 18 years
2.Patients with respiratory failure requiring invasive mechanical ventilation via an endotracheal tube or tracheostomy admitted to the ICU
3.Moderate-severe ARDS as defined by fulfilment of ALL of the following in the last 48 hours:
a.Bilateral opacities in chest x-ray or CT, not fully explained by effusion, lung collapse or nodules
b.Respiratory failure not fully explained by cardiac failure or fluid overload
c.PaO2/FiO2 ratio equal to or less than 150 with a minimum of 5 cmH2O PEEP
Exclusion Criteria
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All-cause mortality assessed by telephone follow-up, searching the National Death Index, data-linkage to medical records etc.[ Day 28]
- Secondary Outcome Measures
Name Time Method se of adjunctive support therapy assessed by accessing information from hospital medical records.[ Day 28];Organ failure assessed by accessing information from hospital medical records..[ Day 7];Ventilator free days assessed by accessing information from hospital medical records.[ Hospital discharge or day 28 whichever occurs first];ICU free days assessed by accessing information from hospital medical records.[ Hospital discharge or day 28 whichever occurs first];DIscharge destination assessed by accessing information from hospital medical records.[ Hospital discharge]