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Clinical Trials/NCT05691374
NCT05691374
Recruiting
Not Applicable

Evaluation of Functional and Biomechanical Outcome by Shear-wave Elastography in the Short to Intermediate Follow-up After Arthroscopic Rotator Cuff Repair

University Hospital, Basel, Switzerland1 site in 1 country75 target enrollmentDecember 22, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Arthroscopic Rotator Cuff Repair (ARCR)
Sponsor
University Hospital, Basel, Switzerland
Enrollment
75
Locations
1
Primary Endpoint
Shear wave propagation velocity in kPa
Status
Recruiting
Last Updated
11 months ago

Overview

Brief Summary

This exploratory project will evaluate the biomechanical and functional intermediate-term outcome (2 to 5 years) after arthroscopic rotator cuff repair (ARCR) with modern non-invasive ultrasound techniques (especially shear wave elastography (SWE)), standardized physical examinations and patient-reported outcomes. It is to evaluate the biomechanical properties of tendons and muscles of the rotator cuff, as well as the biceps muscle after ARCR and to compare elasticity and structural properties to the healthy contralateral side.

Detailed Description

Arthroscopic repair of rotator cuff tears is commonly performed. However, recurrent tears after arthroscopic rotator cuff repair (ARCR) remain a significant clinical problem, especially in cases with large tears. Depending on literature, reported retear rates can range between 13% to 69%. Most likely, these tears reflect mechanical failure of the repair construct. Ultrasound elastography is a recent technology and especially shear wave elastography (SWE) has experienced major developments in the past years. SWE offers an ultrasound based non-invasive quantitative tissue elasticity measurement by evaluating shear wave propagation speed which reflects the biomechanical properties of soft tissue. With this technique, the deltoid and trapezius muscle, several sections of the rotator cuff muscles and tendons as well as the proximal part of the long head of the biceps muscle can be evaluated. Results of the patient-reported outcomes and the physical examinations of the intermediate follow-up (2-5 years) will be compared with the data of the preoperative function. It is a retrospective observational cohort study with additional prospective clinical data collection in terms of a physical examination and ultrasound examination. There is no additional invasive procedure for this study.

Registry
clinicaltrials.gov
Start Date
December 22, 2022
End Date
July 2025
Last Updated
11 months ago
Study Type
Observational
Sex
All

Investigators

Sponsor
University Hospital, Basel, Switzerland
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • year of surgery between 2015 and 2020
  • ARCR surgery in cases of:
  • Partial or complete supraspinatus (SSP) tear
  • Partial or complete supraspinatus (ISP) tear
  • Partial or complete subscapularis (SSC) tear
  • Combined SSP, ISP and SSC tear
  • with or without biceps tenodesis during same procedure
  • able to understand the content of the patient information / consent form and give consent to take part in the study

Exclusion Criteria

  • revision surgery (prior repair of the rotator cuff in the same shoulder)
  • postoperative infections
  • patients with a language barrier hindering questionnaire completion (either in German, French, Italian or English)
  • legal incompetence
  • not eligible for Ultrasound (BMI \>35, persistent frozen shoulder)
  • Prior surgery or injury of the contralateral shoulder

Outcomes

Primary Outcomes

Shear wave propagation velocity in kPa

Time Frame: one time assessment (at least 2 years postoperatively)

Elasticity of tendon and muscle (shear wave propagation velocity in kPa)

Tendon integrity

Time Frame: one time assessment (at least 2 years postoperatively)

Ultrasound of the repaired rotator cuff and biceps tendon (SSP, ISP, SSC, TM, long head of biceps)

Fatty infiltration (SSP, ISP, SSC, TM)

Time Frame: one time assessment (at least 2 years postoperatively)

Fatty infiltration of the repaired rotator cuff (SSP, ISP, SSC, TM) by ultrasound

Status of implants e.g. anchors

Time Frame: one time assessment (at least 2 years postoperatively)

Status of implants e.g. anchors by ultrasound

Diameter/Thickness of rotator cuff tendons (ISP, SSP, SSC, TM)

Time Frame: one time assessment (at least 2 years postoperatively)

Diameter/Thickness of rotator cuff tendons (ISP, SSP, SSC, TM) by ultrasound

Suture cut-through (yes/no)

Time Frame: one time assessment (at least 2 years postoperatively)

Suture cut-through (yes/no) by ultrasound

Secondary Outcomes

  • Change in Constant Murley Score (CMS)(pre- operative, short-term (6 months postoperatively), and intermediate-term (at least 2 years) follow-up)
  • Change in Subjective Shoulder Value (SSV)(pre- operative, short-term (6 months postoperatively), and intermediate-term (at least 2 years) follow-up)
  • Change in Quality of life assessed by EQ-5D-5- questionnaire(pre- operative, short-term (6 months postoperatively), and intermediate-term (at least 2 years) follow-up)
  • Change in shoulder strength (kg) in 90° of abduction measured by handheld dynamometer(pre- operative, short-term (6 months postoperatively), and intermediate-term (at least 2 years) follow-up)
  • Change in Patient-reported shoulder pain (NRS)(pre- operative, short-term (6 months postoperatively), and intermediate-term (at least 2 years) follow-up)
  • Change in Patient-reported shoulder function (ASES)(pre- operative, short-term (6 months postoperatively), and intermediate-term (at least 2 years) follow-up)

Study Sites (1)

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