Steroids for pneumonia in adults in Kenya (SONIA Trial).

Phase 4

• Conditions: Community acquired pneumonia; Respiratory

• Registration Number: PACTR202111481740832
• Lead Sponsor: niversity of Oxford

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-10-27
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 2180

Inclusion Criteria

1.Adults aged 18 years or over
2.Admitted to hospital with a diagnosis of community-acquired pneumonia. Pneumonia will be based on a clinical definition as follows: the presence of at least 2 of the following signs and symptoms for less than 14 days: cough, fever, dyspnoea, haemoptysis, chest pain or crackles on chest examination.
3.Admitted to hospital within the previous 48 hours
4.Provides written informed consent

Exclusion Criteria

1.Hospital acquired pneumonia- defined as pneumonia in a patient who has been in hospital for >48 hours who did not have the symptoms at admission
2.Patients who in the opinion of the attending clinician, require to be treated with steroids.
3.Known or suspected condition which in the opinion of attending clinician requires treatment with steroids, including but not limited to chronic obstructive pulmonary disease, asthma, adrenal insufficiency, Pneumocystis Jirovecii pneumonia (PCP).
4.If the clinician strongly suspects COVID-19 and wants to provide steroids to the patient because of this suspicion, then the patient will be excluded from the trial.
5.Pregnancy or breast feeding
6.Any contraindication to steroid administration
7.Diagnosis of COVID-19 confirmed via PCR of NP/OP swabs (this only applies if test result known at the point of enrollment)

Study & Design

• Study Type: Interventional
• Study Design: Not specified