microRNAs Tool for Stratifying Stage II Colon Cancer
Recruiting
- Conditions
- Colonic NeoplasmsEffects of Chemotherapy
- Interventions
- Device: miRNA tool
- Registration Number
- NCT02635087
- Lead Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
- Brief Summary
The investigators discover the investigators' miRNA tool can be a useful tool to predict the patients with stage II colon who can benefit from chemotherapy.Then the investigators plan to make an observation study that may validation this tool.
- Detailed Description
This is an observation study. The investigators recruit patients who agree to use their postoperative specimen for miRNA tool examination and receive the investigators' follow up.Their receiving chemotherapy or not will decided by their doctors. The investigators just see whether the stratifying tool could predict prognosis.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 630
Inclusion Criteria
- The informed consent has been obtained from the patient.
- With confirmed diagnosis of stage II colon cancer.
- With moderate/good ECOG health rating (PS): 0-1 score.
- The patient receive no anti-cancer treatment before primary surgery.
- The patient receive radical operation for colon cancer with negative margin.
Exclusion Criteria
- With severe comorbidities, such as cardiovascular disease, chronic obstructive pulmonary disease, diabetes mellitus, and chronic renal dysfunction.
- With bad compliance or contraindication to enrollment.
- Pregnant woman or lactating woman.
- With contraindication to receive adjuvant chemotherapy.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description high risk group miRNA tool the miRNA tool predict this group of patients as "high risk"
- Primary Outcome Measures
Name Time Method DFS 3 years
- Secondary Outcome Measures
Name Time Method OS 5 years
Trial Locations
- Locations (1)
FisrtSunYetsen
🇨🇳Guangzhou, Guangdong, China