TAILOR-AHF: randomized controlled trial investigating a tailored diuretic algorithm in acute heart failure patients

Recruiting

• Conditions: Heart failure; pump failure; 10019280

• Registration Number: NL-OMON53791
• Lead Sponsor: Zuyderland Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 466

Inclusion Criteria

• Age > 18 years; • HF (HFrEF, HFmrEF or HFpEF) diagnosed according to the 2021
HF Guidelines of the European Society of Cardiology; • Presentation with AHF
meaning at least one symptom (dyspnea, orthopnea, or edema) and one sign
(rales, peripheral edema, ascites, or pulmonary vascular congestion on chest
radiography) of AHF; • An elevated NT-proBNP >300pg/ml; • Requiring the need
for iv diuretics;

Exclusion Criteria

• Terminal renal insufficiency defined as: dialysis patients or eGFR (estimated
glomerular filtration rate) < 10 mL/min/1.73 m2; • Patients included in other
investigational studies regarding heart failure. • Presentation with
cardiogenic shock or respiratory insufficiency or another reason requiring
admission to the intensive care unit upon admission (IC transfer later in the
hospitalization is not an exclusion).

Study & Design

• Study Type: Interventional
• Study Design: Not specified