Uncontrolled Donation After Circulatory Determination of Death (uDCDD): A Potential Solution to the Shortage of Organs in Quebec?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,111
- 主要终点
- Potential contribution of a uDCDD program on the number of additional donors.
研究概览
简要总结
World-wide, patients waiting for organ transplantation exceed the number of organs available. Many European countries have a uDCDD program which contribute to 10-15% of the donor pool. In Canada, this type of program does not exist. The purpose of this study is to report how many deceased person fulfill the criteria for uncontrolled DCDD in a Canadian medical center.
详细描述
While transplantation has become the definitive treatment for many people suffering end-stage organ failure, demand exceeds supply. For many years, donation after neurological death represented the principal source of organs for transplantation. In the last decade, prevention measures, improvements in neurocritical care, and decompressive craniectomy have led to a significant decrease in the number of non-directed donors (NDDs). In such situations, alternative sources for organ donation must be identified. Cardiac-arrest patients could provide a solution to this organ shortage. Patients who have experienced unexpected in or out of hospital cardiopulmonary arrest could become organ donors. Organ donation following uncontrolled cardiocirculatory death is currently practiced in many European countries. However, in Canada, it's not yet authorized. Yet, each deceased could save up to four lives. The purpose of this study is to determine the organ potential for a cohort of patient who had died from a cardiopulmonary arrest at the CHUS in 2015 and assess the effect of the implementation of a uDCD program on the number of additional donors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients treated for cardiocirculatory arrest at the CIUSSS-Estrie CHUS in 2015.
排除标准
- •Patients with a status of no resuscitation
- •Pediatric patients (<18 years old)
- •Adults >65 years old
结局指标
主要结局
Potential contribution of a uDCDD program on the number of additional donors.
时间窗: 1 year
Defined as (must meet all criteria): * Age ≤70 years old * Absence of obvious cause of death (rigor mortis, decapitation, overwhelming traumatic injury) * Absence of surgical cause of cardiac arrest * No sign of IV drug abuse * No history of malignancies
次要结局
- Areas of future research.(1 year)
- Number of tissus donors(1 year)
- Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.(1 year)
- Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.(1 year)
