A pilot study evaluating the effect of platelet transfusion using an electromechanical infusion pump versus conventional gravity flow method
Not Applicable
Completed
- Conditions
- Platelet transfusionBlood - Haematological diseases
- Registration Number
- ACTRN12609000597291
- Lead Sponsor
- Clifford Craig Medical Trust Foundation
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 240
Inclusion Criteria
Patients requiring a platelet infusion.
Exclusion Criteria
1. Patients with severe infection/ sepsis with temperature>38.5 C.
2. Patients with coagulopathy / DIC
3. Patients with platelet refractoriness e.g. platelet antibody or human leucocyte antigen (HLA) antibody.
4. Patients under the age of 18 years.
5. Patients with an intellectual or mental impairment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The aim of this pilot study is to evaluate whether infusion method influences the quality and quantity of platelets transfused.<br>Platelets count and function will be assessed after transfusion via full blood count and flow cytometry techniques.[Main outcome will be measured by platelet count prior to transfusion and platelet count increment after 60 min of completion of transfusion as well as 24 hours post platelet transfusion recovery as per current <br>standard practice.]
- Secondary Outcome Measures
Name Time Method To determine the most efficient procedure for the administration of platelets. <br>Also whether the rate and method of transfusion influences the quality and quantity of platelets transfused. Platelets count and function will be assessed after transfusion via full blood count and flow cytometry techniques.[Until the end of study Dec 2009];Other factors that might influence platelet recovery include presence of infection/ Dissiminated intravascular coagulopathy (DIC), drugs administration and occurrence of transfusion reactions. These will be studied and recorded as per protocol for correlation with platelet recovery. <br>Studying the effect of the rate of transfusion via a pump will also be examined and recorded.[Until the end of study Dec 2009]