Oxycodone in Combination With Parathoracic Nerve Block is Used for Postoperative Analgesia in Lung Cancer
- Conditions
- Oxycodone
- Interventions
- Registration Number
- NCT05742256
- Lead Sponsor
- Qianfoshan Hospital
- Brief Summary
In this study, the effect of oxycodone combined with ultrasound-guided paravertebral nerve block on the postoperative analgesic effect of thoracoscopic lung cancer was investigated, and the effect and reasonable dose of oxycodone were explored, which provided a reference for the clinical multimodal analgesia after thoracoscopic lung cancer surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 159
- Male or female, age > 60 years
- Patients undergoing thoracoscopic lobectomy
- ASA (American Academy of Anesthesiologists) Grades I-III
- There were no obvious abnormalities in heart, liver, and kidney function
- Sign the informed consent form for this clinical study
- History of oxycodone or sufentanil allergy
- Renal or hepatic dysfunction
- History of drug or alcohol abuse
- Psychiatric disorders: schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis
- Those who have difficulty communicating due to coma, severe dementia, speech barrier, or those who cannot cooperate due to other diseases.
- People with head trauma or other brain diseases -
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Test group 1(OCA group) Oxycodone 1mg/kg - Test group 2(OCB group) Oxycodone 1.5mg/kg - Control group(SF group) Sufentanil -
- Primary Outcome Measures
Name Time Method The main indicators were NRS scores at rest and cough at 24 h postoperatively. at 24h after surgery NRS (numerical rating scale) is composed of 11 numbers from 0 to 10, and patients use 11 numbers from 0 to 10 to describe the intensity of pain, and the higher the number, the more severe the pain.
- Secondary Outcome Measures
Name Time Method Time to double-lumen tracheal extraction Within two hours after surgery Time to double-lumen tracheal extraction
NRS score at rest and cough at 2h , 4h, 12h, 48h after surgery NRS (numerical rating scale) is composed of 11 numbers from 0 to 10, and patients use 11 numbers from 0 to 10 to describe the intensity of pain, and the higher the number, the more severe the pain.
sedation score (Ramsay sedation score) at 2 h , 4 h , 12 h ,24 h,48 h postoperatively The Ramsay sedation score is the most widely used sedation scoring criterion in clinical practice. It is divided into six levels, reflecting three levels of wakefulness and three levels of sleep. The higher the level, the deeper the level of sedation.
sufentanil consumption Within 48 hours after surgery sufentanil consumption
oxycodone consumption Within 48 hours after surgery oxycodone consumption
analgesic pump compressions Within 48 hours after surgery analgesic pump compressions
additional analgesic doses Within 48 hours after surgery additional analgesic doses
incidence of adverse reactions: nausea, vomiting, respiratory depression, dizziness, itchin Within 48 hours after surgery incidence of adverse reactions: nausea, vomiting, respiratory depression, dizziness, itchin
gastrointestinal recovery (exhaust time) Within 48 hours after surgery gastrointestinal recovery (exhaust time)
laboratory results of C-reactive protein 1 day before and after surgery Within 48 hours after surgery laboratory results of C-reactive protein 1 day before and after surgery
laboratory results of interleukin-6 laboratory test 1 day before and after surgery Within 48 hours after surgery laboratory results of interleukin-6 laboratory test 1 day before and after surgery