NCT00509704已完成不适用
Pilot Study on the Influence of Sutent on Tumor Vascularization and Necrosis in Patients With Renal Cell Carcinoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
研究概览
简要总结
The purpose of the study is to assess the effect of Sunitinib on tumor vascularization and necrosis in patients with metastatic renal cell cancer.
详细描述
Sutent is an angiogenesis inhibitor used in the treatment of renal cell cancer. Very often tumor necrosis is seen after the start of the treatment. It is unknown after how many days this effect starts. In patients with renal cell cancer with metastases, who will be treated with Sutent, 3 MRIs will be made. Kep, R2*, b-coefficient (perfusion, hypoxia, blood volume and necrosis) will be measured.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with metastatic renal cell cancer for whom treatment with Sunitinib is planned
- •histologically verified stage IV renal cell carcinoma of clear cell type
- •measurable primary tumor or metastases (minimal diameter 2 cm) at other sites than the lungs
- •Karnofsky score > 70%
- •age > 18 year.
- •written informed consent
排除标准
- •contra-indications for MRI
- •contra-indications for treatment with Sunitinib
- •previous systemic treatment within the last 30 days
研究者
研究点 (1)
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