Effect of combined vitamin E and zinc supplementation in treatment of gestational diabetes mellitus

Phase 3

Conditions: Gestational diabetes mellitus.
Unspecified diabetes mellitus in pregnancy, childbirth and the puerperium
O24.9

Registration Number: IRCT20170513033941N26

Lead Sponsor: ational Institute for Medical Research Development of Iran (NIMAD)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 60

Inclusion Criteria

Patients with gestational diabetes mellitus.
Individuals aged 18 to 40 years.

Exclusion Criteria

Taking zinc and vitamin E supplements 3 months before the intervention
Insulin therapy required during the intervention
Pre-eclampsia
Eclampsia
Hypo and hyperthyroidism

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Insulin. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Elisa kit.;Insulin resistance. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Calculation using HOMA formula.

Secondary Outcome Measures

Name	Time	Method
Total cholesterol. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Enzymatic kit.;HDL. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Enzymatic kit.;Triglycerides. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Enzymatic kit.;Expressed levels of PPAR-? gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.;LDL-cholesterol. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Enzymatic kit.;VLDL-cholesterol. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: Enzymatic kit.;Expressed levels of LDLR gene. Timepoint: At the beginning of the study and after 6 weeks of intervention. Method of measurement: PCR.