The Comparison of Autologous Cultured Fibroblast and Hyaluronic Acid Filler in the Treatment of Nasolabial folds: A Pilot Study
- Conditions
- patients who expressed dissatisfaction with their nasolabial folds based on a score of -1 or -2 on the Subject Wrinkle Assessment ScaleNasolabial fold
- Registration Number
- TCTR20220217002
- Lead Sponsor
- Research department, Faculty of Medicine Siriraj Hospital
- Brief Summary
Autologous fibroblast injection is a safe and effective treatment for NLFs. Unlike conventional fillers, the autologous cultured fibroblast cells are injected more superficially and may require a longer period to show improvement. It also offers the promise of sustained growth of living cells, which may lead to greater persistence than other fillers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 55
patients who expressed dissatisfaction with their nasolabial folds based on a score of -1 or -2 on the Subject Wrinkle Assessment Scale
(1) were pregnant or lactating; (2) had a history of connective tissue disorder, skin cancers, or related diseases; (3) had previous autologous fibroblast treatment; (4) had previous treatment with fillers, lasers or energy-based devices within the last 12 months; (5) had previous treatment using transdermal drug delivery, chemical peeling or topical retinoid within the last month; or (6) had allergy to collagen, meat and dairy products, gentamycin, amphotericin B, or related products.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method clinical improvement 1-, 3-, 6-, and 12-months follow-up increation of facial volume captured by Vectra H1 Imaging System
- Secondary Outcome Measures
Name Time Method safety 1-, 3-, 6-, and 12-months follow-up history taking and physical examination