Differential Expression and Analysis of Peripheral Plasma Exosome miRNA in Patients With Myocardial Infarction

• Conditions: Myocardial Infarction

• Registration Number: NCT04127591
• Lead Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Brief Summary

The aim of this study is to determine the miRNA expression profile in peripheral blood exosomes of patients with myocardial infarction and to investigate its relationship with myocardial infarction.

Detailed Description

Collect exosomes in peripheral blood of patients with myocardial infarction, compare the expression of miRNA with healthy volunteers, find out the miRNAs with significant differences, and explore its relationship with the development of myocardial infarction.

Study Timeline

• Status Verified: 2019-10
• Study First Submitted: 2019-10-14
• Study First Submitted QC: 2019-10-14
• Last Update Submitted: 2019-10-14
• Study First Posted: 2019-10-15
• Last Update Posted: 2019-10-15
• Study Start: 2019-10-20
• Primary Completion: 2021-12-30
• Study Completion: 2021-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Age > 18 years ST elevation by ECG diagnostic of STEMI Evidency of coronary occlusion in coronariography Signed informed consent

Exclusion Criteria

• Patients who will undergo immediate PCI Pregnant and lactating women Patients with mental disorders Patients are using other experimental drugs; Refusal to provide informed.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of differential expression of miRNA by second-generation sequencing technology	Day 7

Secondary Outcome Measures

Name	Time	Method
Diagnostic value of the differential microRNAs evaluate by qPCR in patients of myocardial infarction	Day 7

Trial Locations

Locations (1)

Ethics Committee of Xinhua Hospital; 🇨🇳 Shanghai, Shanghai, China