Histidine depletion as a new method to examine the association of histamine and cognition in humans

Completed

Conditions: geen aandoening
nvt

Registration Number: NL-OMON30268

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 18

Inclusion Criteria

male or female, between 18 and 35 years of age, healthy (absence of exclusion criteria), normal static binocular acuity, body mass index between 18.5 and 30, willingness to sign an informed consent.

Exclusion Criteria

history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological or psychiatric illness, excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of a psychiatric disorder will also be excluded.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoint is the behavioural score on the critical tracking task, a<br /><br>task that measures psychomotor performance. Secondary, the behavioural and<br /><br>event-related potential response during simple and choice reaction time tasks<br /><br>will be analysed. A further important parameter is the change in histidine<br /><br>blood plasma level after histidine depletion.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary are the behavioural and brain activity scores during a verbal<br /><br>learning task, the Sternberg working memory scanning, and a visual oddball<br /><br>paradigm. These tasks enable us to assess the specificity of the effects of<br /><br>histidine depletion.</p><br>