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Clinical Trials/CTRI/2025/05/087891
CTRI/2025/05/087891
Recruiting
Phase 3 4

Comparative analysis of pain perception during administration of local anesthesia using a novel device

Shree Guru Gobind Singh Tricentenary University1 site in 1 country100 target enrollmentStarted: June 2, 2025Last updated:

Overview

Phase
Phase 3 4
Status
Recruiting
Enrollment
100
Locations
1
Primary Endpoint
effect of pain perception using BioVibe-DentaPatch (BVDP) - a novel device during administration of local anesthesia.

Overview

Brief Summary

**Introduction:**Dental anxiety and fear of needles hinder timely treatment, with intraoral injections being a major source of pain and discomfort. Pain perception varies based on factors like injection site and patient sensitivity among kids and adults.Traditional pain management methods include topical anesthetics and slow injection techniques, while non-pharmacological strategies like vibratory stimulation offer promising alternatives.Vibratory devices such as DentalVibe and VibraJect reduce injection pain via the Gate Control Theory. However, no bioadhesive vibrating patch exists yet. The study aims to evaluate BioVibe-DentaPatch (BVDP), a novel vibratory patch, in reducing injection pain in adults using the Visual Analogue Scale (VAS).

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Objectives:

  1. To evaluate the effect of pain perception using BioVibe-DentaPatch (BVDP) - a novel device during administration of local anesthesia.

  2. To compare the pain perception during administration of local anesthesia with and without BioVibe-DentaPatch (BVDP) - a novel device in patients undergoing dental procedures.

3.To evaluate and compare the pain perception using coolant and BioVibe-DentaPatch (BVDP)- a novel device during administration of local anesthesia in patients undergoing dental procedures.

Materials and methodology:

1.Endo Ice sticks

2.2% lignocaine with 1: 100,000 epinephrine (ICPA Xicaine, India)

  1. 21-mm aspirating type syringe, 27-gauge needle (Dispovan)

4.BioVibe- DentaPatch (BVDP)

A sample size of 100 patients will be chosen as per inclusion criteria. The subjects will be from the Department of Conservative Dentistry and Endodontics, Faculty of Dental Scienes, SGT Dental College, Gurugram. They are then divided into 2 groups- 50 patients per group.

Group A- local anesthesia administration without BVDP

Group B- local anesthesia administration with BVDP

Subgroup b1: local anesthesia administration with BVDP but without cryotherapy (ie., without use of coolant) n=25

Subgroup b2: local anesthesia administration with BVDP and cryotherapy (ie., use of coolant) n=25

Study Design

Study Type
Interventional
Allocation
Randomized
Masking
None

Eligibility Criteria

Ages
18.00 Year(s) to 60.00 Year(s) (—)
Sex
All

Inclusion Criteria

  • Patient aged 18 years and above
  • Patients who require local anesthetic injections prior dental procedure
  • Patients who are willing to participate.

Exclusion Criteria

  • Subjects with systemic medical conditions
  • Patients with problems in comprehension
  • Patients allergic to local anesthetic agents.

Outcomes

Primary Outcomes

effect of pain perception using BioVibe-DentaPatch (BVDP) - a novel device during administration of local anesthesia.

Time Frame: degree of pain during the local anesthetic injections using Visual Analog Scale (VAS) will be recorded within five minutes of application. outcome will be assessed at baseline.

Secondary Outcomes

  • compare the pain perception during administration of local anesthesia with and without BioVibe-DentaPatch (BVDP) - a novel device in patients undergoing dental procedures(degree of pain during the local anesthetic injections using Visual Analog Scale (VAS) will be recorded within five minutes of application)
  • pain perception using coolant & BioVibe-DentaPatch (BVDP)- a novel device during administration of local anesthesia in patients undergoing dental procedures.(degree of pain during the local anesthetic injections using Visual Analog Scale (VAS) will be recorded within five minutes of application. outcome will be assessed at baseline)

Investigators

Sponsor Class
Research institution and hospital
Responsible Party
Principal Investigator
Principal Investigator

Dr Aishley Jain

Shree Guru Gobind Singh Tricentenary University

Study Sites (1)

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