Determining Clinical Profile of Parkinson's Disease Among Egyptian Population
试验速览
- 阶段
- 不适用
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Non-motor symptoms
研究概览
简要总结
Parkinson's disease is the second most common neurodegenerative disease affecting about 1-3% of population above 60 years. Recently, non-motor symptoms are getting more attention in PD management. The pattern of PD onset and clinical course differ from one population to another. Many studies have been conducted to determine the clinical profile of PD in populations worldwide. However, no similar studies have been conducted in Egypt. Therefore, the investigators will conduct a nation-wide, collaborative, cross sectional study to determine the pattern of Parkinson's disease onset, clinical course, and non-motor symptoms among Egyptian population.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who meet the Parkinson's disease criteria of United Kingdom Brain Bank within the study centres.
排除标准
- •Patients with vascular Parkinsonism (history of stroke)
- •Patients with treatment induced Parkinsonism
- •Patients with history of dopaminergic neurotoxin (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
结局指标
主要结局
Non-motor symptoms
时间窗: At enrolment
Non-motor symptoms measured by the non-motor symptoms questionnaire (NMS)
Side of initial motor symptoms
时间窗: At enrolment
Number of patients with either right or left side initial motor symptoms.
Levodopa equivalent dose
时间窗: At enrolment
Current dose of levodopa per day
Time to diagnosis
时间窗: At enrolment
Duration, in years, from appearance of initial symptom to receiving Parkinson's disease diagnosis.
Initial motor symptom
时间窗: At enrolment
Number of patients with each initial motor symptom (tremor, rigidity, or bradykinesia).
Quality of life
时间窗: At enrolment
Mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort assessed by the parkinson's disease quality of life questionnaire (PDQ-39).
Age at disease onset
时间窗: At enrolment
Patients age when the initial symptom appeared.
Clinical subtype of the disease
时间窗: At enrolment
Number patients with each disease subtype (tremor dominant Parkinson's disease, hypokinetic-rigid dominant Parkinson's disease, or postural instability and gait disturbance dominant Parkinson's disease).
Duration of levodopa treatment from disease onset
时间窗: At enrolment
Number of years on levodopa treatment since receiving parkinson's disease diagnosis
次要结局
- Stage of the disease [optional](At enrolment)
- Motor Functions [optional](At enrolment)
研究者
Ahmed Negida
(1) Principal Investigator; (2) Head of Scientific Committee, Student Research Unit, Zagazig University; and (3) Head of Scientific Committee, Egyptian National Research Collaborative.
Zagazig University