NCT01765322UnknownNot Applicable
Center of Assisted Reproductive Technology
Shanxi Provincial Maternity and Children's Hospital1 site in 1 country150 target enrollmentStarted: November 1, 2013Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- The implantation rate
Study Overview
Brief Summary
The purpose of this study is to determine whether laser-assisted zona thinning improve the implantation rate of the women of advanced age in the first IVF/ICSI cycles
Detailed Description
Registry procedures：
- It's required to sign an informed consent form prior to the recruitment of all patients.
- Data collection and entry need double check and supervision.
The outcome measures:
the implantation rate per embryo transfer miscarriage live birth
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 35 Years to 46 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age: 35y ≤age≤46y
- •Basal FSH value: FSH≤10IU/L
- •Day-3 embryos transferred in the fresh IVF/ICSI cycles
- •the number of embryos available to be transferred on Day-3: ≥one embryo
Exclusion Criteria
- •cycles with thawed/warmed embryos biopsied for PGD/PGS.
- •cycles with oocyte donation transfer.
- •the maximum number of previous unsuccessful IVF attempts: ≥ 3 cycles(transfer cycles)
- •any cycles with the risk of OHSS, fluid in the uterine cavity, abnormal endometrium, uterine abnormalities,pelvic inflammation, and other acute maternal problems.
- •One or both spouses have an abnormal karyotype (including polymorphism)
Outcomes
Primary Outcomes
The implantation rate
Time Frame: 30 days
the implantation rate per embryo in first fresh embryos transfer cycles
Secondary Outcomes
- The miscarriage(24 weeks)
Investigators
Shi Wenhao
Assisted Reproductive Technology Center
Shanxi Provincial Maternity and Children's Hospital
Study Sites (1)
Loading locations...
Similar Trials
Not yet recruiting
Not Applicable
effect of laser hatching in endometriosisPACTR201602001467322Gannah IVF center100
Terminated
Not Applicable
Laser Treatment for the Improvement of Scars and SclerodermaScarsSclerodermaNCT04567537Massachusetts General Hospital6
Completed
Not Applicable
Low Level Laser Light Therapy as an Aid to LiposuctionPainNCT00927277Erchonia Corporation70
Terminated
Not Applicable
Laser - a New Possibility in Fertility Treatment - a Pilot StudyExposure LaserInfertilityNCT02594852Regionshospitalet Viborg, Skive20
Completed
Not Applicable
Laser-assisted ICSI Versus Conventional ICSIInfertilityNCT03665103Ibn Sina Hospital966