The comparison of 2 types of heparin ( unfractionated vs low molecular weight heparin) in patients with stroke due to atrial fibrillatio

Phase 2

Conditions: Condition 1: ischemic stroke. Condition 2: persistent atrial fibrillation. Condition 3: chronic atrial fibrillation. Condition 4: paroxysmal atrial fibtillation.
A disorder characterized by a sudden loss of sensory function due to an intracranial vascular event. A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to brain ischemia or intracranial hemorrhages
Atrial fibrillation and flutter
Continuous or recurrent bouts of atrial fibrillation.
Sudden and episodic bouts of atrial fibrillation.

Registration Number: IRCT2014020213698N1

Lead Sponsor: Shiraz University of Medical Scienses

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 80

Inclusion Criteria

Inclusion Criteria:

confirmed diagnosis of acute ischemic stroke purely due to AF
AF confirmed by ECG or 24 hour holter monitoring
Patients who need initiation of anticoagulation for prevention of recurrent stroke

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Exclusion Criteria

ages less than 18 or more than 75
no cooperation
CNS hemorrhage
major bleeding
infarction size of more than one third of MCA territory
NIHS score more than 20
hypersensitivity to IV UFH or LMWH
no informed consent
other causes for stroke except AF
pregnancy
breast feeding
uncontrolled HTN (BP more than 220/120)
renal, hepatic, respiratory or cardiac failure
myocardial infarction
infectious endocarditis
coma
vasculitis
dissection

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality. Timepoint: 7 days and 90 days after stroke. Method of measurement: close observation in hospital and telephone interview after discharge.;Ischemic stroke. Timepoint: 7 days and 90 days after stroke. Method of measurement: CT scan and daily physical examination.;Hemorrhagic stroke. Timepoint: 7 days and 90 days after stroke. Method of measurement: CT scan and daily physical examination.

Secondary Outcome Measures

Name	Time	Method
Symptomatic CNS hemorrhage. Timepoint: 7 days and 90 days after stroke. Method of measurement: CT scan.;Non-CNS hemorrhage. Timepoint: 7 days and 90 days after stroke. Method of measurement: CT scan.;Asymptomatic CNS_hemorrhage. Timepoint: 7 days and 90 days after stroke. Method of measurement: CT scan.;Time to reach target INR. Timepoint: average time is 7 to 10 days (it is variable between individuals). Method of measurement: laboratory.;Tolerability of drugs. Timepoint: during hospital admission while the patient is receiving anticoagulant. Method of measurement: daily physical exam.