Modification of Rhythmic Risk Assessment by Ventricular Tachycardia Ablation

• Conditions: Ventricular Tachycardia

• Registration Number: NCT03453645
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

Sudden cardiac death is a frequent cause of cardiovascular mortality. Numerous rhythmic risk assessment criterion have been described targeting the substratum, the cardiac nervous tone or the trigger of arrhythmias. Development of ventricular tachycardia ablation in the past few years show interesting results preventing the recurrence of ventricular arrhythmias.

Detailed Description

Sudden cardiac death is a frequent cause of cardiovascular mortality. Numerous rhythmic risk assessment criterion have been described targeting the substratum, the cardiac nervous tone or the trigger of arrhythmias. Development of ventricular tachycardia ablation in the past few years show interesting results preventing the recurrence of ventricular arrhythmias.

Rhythmic risk assessment criterions have never been studied in relation with ventricular tachycardia ablation. The purpose of this study is to explore the modifications of these criterions after ventricular tachycardia ablation.

Study Timeline

• Study First Submitted: 2017-07-27
• Study Start: 2017-09-09
• Study First Submitted QC: 2018-02-26
• Study First Posted: 2018-03-05
• Status Verified: 2018-07
• Last Update Submitted: 2018-07-10
• Last Update Posted: 2018-07-11
• Primary Completion: 2018-09
• Study Completion: 2019-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients undergoing ventricular tachycardia,
• patients with ischemic cardiomyopathy according to European Society of Cardiology Guidelines,
• patients with implanted cardiac defibrillator.

Exclusion Criteria

• Contra-indication to stress test,
• permanent atrial fibrillation,
• permanent ventricular pacing,
• left bundle block.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
measure assessing change before and after Ventricular Tachycardia Ablation of the non-invasive parameters analysis of the rhythmic risk before and after Ventricular Tachycardia Ablation	10 minutes and 60 minutes after the Ventricular Tachycardia Ablation	non invasive parameters analysis of the rhythmic risk will be evaluated by the evaluation of the T wave alternans

Secondary Outcome Measures

Name	Time	Method
Study of the correlation between the modifications of non-invasive parameters analysis of the rhythmic risk and the success of the ablation procedure	3 months, 6 months and 12 months after the Ventricular Tachycardia Ablation	Success of the ablation procedure is defined by the absence of inducible Ventricular Tachycardia at the end of the procedure.
Assessing the correlations of the modifications of the risk criterion after ablation with the recurrences of arrhythmias at one year follow-up	3 months, 6 months and 12 months after the Ventricular Tachycardia Ablation	the recurrences of arrhythmias will be evaluated . There will be assessed by the informations reveled by the Implantable automatic defibrillator

Trial Locations

Locations (1)

University Hospital of Toulouse; 🇫🇷 Toulouse, France