Effects of Repetitive Transcranial Magnetic Stimulation on Neural and Behavioral Facets of Social Cognition in Autism Spectrum Disorder
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- right lateralized N170 latency to upright faces
研究概览
简要总结
This study will evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on neural and behavioral facets of social cognition in Autism Spectrum Disorder (ASD). Participant visits will include a baseline assessment of neuropsychological, cognitive and behavioral function, and an EEG (electroencephalogram) and eye-tracking session to measure neural and visual attentional social response before and after administration of TMS.
详细描述
Broad ranging social cognition difficulties are hallmark areas of impairment in autism spectrum disorder (ASD), and they are subserved by specific neural systems underpinning social perception and processing that are recognized to be atypical in ASD. Considering the neurodevelopmental nature of the disorder, and the recent findings regarding aberrant neuroplasticity in ASD, repetitive transcranial magnetic stimulation (rTMS) holds promise to directly modulate brain activity in these systems. The objective of this research proposal is to utilize a multimodal approach to provide a proof-of-concept for the ability of rTMS to (a) influence functioning in the brain systems involved in social ASD symptomatology and (b) modify associated social cognitive behaviors in adults with ASD. Toward achieving this objective, we propose to assess critical aspects of social cognition using the electroencephalogram (EEG), event-related potentials (ERPS), eye-tracking (ET), and behavioral tasks prior to and following a single rTMS session to provide preliminary insight into the potential of rTMS as a tool to modify social brain function in cognitively able adults with ASD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •individuals between the ages of 18 and 40 years old with typical development or with a diagnosis of autism spectrum disorder.
- •able to participate in an EEG and eye-tracking experiment
排除标准
- •Participants reporting significant head trauma or serious brain illness
- •Participants with major psychiatric illness that would preclude completion of study measures.
- •Participants with a history of serious medical illness, stroke, seizures, epileptiform EEG abnormalities, or family history of seizures.
- •Participants taking prescription medications that may affect cognitive processes under study.
- •Participants who have taken alcohol or recreational drugs within the preceding 24 hours.
- •Females of known/suspected pregnancy or who test positive on a pregnancy test.
- •Participants with a history of metalworking or injury by shrapnel or metallic objects are also exclude
研究组 & 干预措施
Transcranial Magnetic Stimulation - real
Participants will receive active TMS during their study visit
干预措施: Transcranial Magnetic Stimulation (TMS) (Behavioral)
Transcranial Magnetic Stimulation - sham
Participants will receive sham stimulation during their study visit simulating TMS
干预措施: Transcranial Magnetic Stimulation (TMS) (Behavioral)
结局指标
主要结局
right lateralized N170 latency to upright faces
时间窗: Measures will be recorded for the duration of their visit, an expected average of 4-5 hrs.
EEG brain response to faces as measured by the N170 component in milliseconds
次要结局
- proportion of visual attention to the eye region of the face(Measures will be recorded for the duration of their visit, an expected average of 4-5 hrs.)
- The Benton Face Recognition Task(Measures will be recorded for the duration of their visit, an expected average of 4-5hrs)
研究者
James C. McPartland
Associate Professor of Child Psychiatry and Psychology
Yale University