NCT06557967已完成不适用
Prevalence of Brain Metastases and Impact on Survival in Metastatic Non-small Cell Lung Cancer by Line of Treatment
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22,517
- 试验地点
- 1
- 主要终点
- Overall Survival (OS) of (AGA+/-) mNSCLC Participant With And Without Brain Metastases by Line of Therapy
研究概览
简要总结
This study will use real-world data to assess prevalence of brain metastases in metastatic non-small cell lung cancer (mNSCLC) patients and its impact on associated clinical outcomes.
详细描述
This retrospective cohort database study will generate real-world evidence describing prevalence of brain metastases at metastatic diagnosis and by line of therapy, patient characteristics, treatment patterns, and clinical outcomes in metastatic non-small cell lung cancer (mNSCLC) patients
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of mNSCLC in study period (01/01/2015-06/30/2023) including newly diagnosed at metastatic stage or progression from advanced stage NSCLC
- •Age 18+ years at the time of diagnosis of mNSCLC
- •Additional inclusion criteria for 1st Line of Therapy cohort:
- •Treated with systemic anti-cancer therapy in 1L setting
- •Additional inclusion criteria for 2nd Line of Therapy and 3rd Line of Therapy cohorts:
- •Treated with systemic anti-cancer therapy in 2L setting treated with systemic anti-cancer therapy in 3L setting
排除标准
- •Evidence of other primary malignancy in the 365-day baseline period immediately prior to the first mNSCLC diagnosis in the study period
- •Evidence of stereotactic radiosurgery (SRS), stereotactic radiation therapy (SRT), or whole brain radiotherapy (WBRT) in the baseline period
结局指标
主要结局
Overall Survival (OS) of (AGA+/-) mNSCLC Participant With And Without Brain Metastases by Line of Therapy
时间窗: From baseline to end of follow-up or death, whichever comes first, up to approximately 40 months.
次要结局
未报告次要终点
研究者
研究点 (1)
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