The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.

Phase 4

• Conditions: Poor Responders Undergoing IVF
• Interventions: Drug: GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG); Drug: microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono); Drug: Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma); Drug: GnRH antagonist protocol (Cetrotide, Serono)

• Registration Number: NCT01948804
• Lead Sponsor: Pınar Özcan Cenksoy

Brief Summary

The comparison of effect of four different treatment protocols: Antagonist/letrozole protocol, microdose flare-up protocol, Antagonist/clomiphene protocol, Antagonist on IVF outcomes in poor responders undergoing in vitro fertilization; a prospective randomized-controlled study.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-09-06
• Study First Submitted QC: 2013-09-18
• Study First Posted: 2013-09-24
• Status Verified: 2014-01
• Study Start: 2014-01
• Last Update Submitted: 2014-01-14
• Last Update Posted: 2014-01-15
• Primary Completion: 2014-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

Criteria for definition of poor responders included at least one of the following

1. Anti müllerian hormone <1.1 ng/ml and/or a previous poor ovarian response (≤3 oocytes with a conventional stimulation protocol).
2. Primary infertile patients
3. BMI≤30 kg/m2 were included this study.

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
IVF patients	GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG)	patients that has applied to Yeditepe University Hospital assisted reproduction center
IVF patients	GnRH antagonist protocol (Cetrotide, Serono)	patients that has applied to Yeditepe University Hospital assisted reproduction center
IVF patients	microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono)	patients that has applied to Yeditepe University Hospital assisted reproduction center
IVF patients	Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma)	patients that has applied to Yeditepe University Hospital assisted reproduction center

Primary Outcome Measures

Name	Time	Method
clinical pregnancy rates	6 months

Secondary Outcome Measures

Name	Time	Method
total number of oocytes retrieved	6 months