Personalising immunosuppression in liver transplantatio
Not Applicable
Recruiting
- Conditions
- iver transplantationSolid organ rejectionInfectionLiver transplantationOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colonInflammatory and Immune System - Other inflammatory or immune system disordersInfection - Other infectious diseasesSurgery - Other surgery
- Registration Number
- ACTRN12619001016123
- Lead Sponsor
- A/Prof Vijayaragavan Muralidharan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 210
Inclusion Criteria
• Age 18 years and above.
• Undergoing LT at Austin Health.
• Can provide written informed consent.
Exclusion Criteria
• Aged under 18 years.
• Undergoing multi-organ transplantation.
• Unable to provide written informed consent at any stage.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The accuracy of QFM and dscfDNA, alone and in combination, compared to LFTs to diagnose: the first episode of tBPAR, as measured by the area under the receiver operator<br>curve (AUC) established according to liver biopsy and medical records.[Pre-transplantation, post-transplant (day 1, 3 and 5; week 1 and 2; month 1, 2 4, 6 and 12) and at if an episode of tBPAR or infection occurs (3 timepoints, 1-3 days apart). <br><br>No timepoint is considered to be primary.];The accuracy of QFM and dscfDNA, alone and in combination, compared to LFTs to diagnose the first episode of infective complication, as measured by the AUC established according to medical records.[Pre-transplantation, post-transplant (day 1, 3 and 5; week 1 and 2; month 1, 2 4, 6 and 12) and at if an episode of tBPAR or infection occurs (3 timepoints, 1-3 days apart). <br><br>No timepoint is considered to be primary.]
- Secondary Outcome Measures
Name Time Method