The Effect of Anesthesia on the Recruitment of Motor Evoked Potentials Using an Increased Number of Pulses
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Effect of Pulse Train Length on Transcranial Motor Evoked Potentials (TcMEP) Area Under Total Intravenous Anesthesia (TIVA) and TIVA Plus 3% Desflurane
研究概览
简要总结
Test the hypothesis to recruit larger motor responses to transcranial stimulation.
详细描述
The study is designed to test the hypothesis that it is possible to recruit larger motor responses to transcranial stimulation by increasing the number of stimulating pulses under both baseline conditions and conditions of increased anesthetic suppression of the motor responses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 12 through 17 years
- •Diagnosis of idiopathic scoliosis
- •Scheduled for posterior spinal fusion with neurophysiological monitoring
- •No known allergies to propofol or remifentanil
- •No contraindication to total intravenous anesthesia
- •No contraindications to the administration of volatile agents
排除标准
- •Failure to consent or assent to study
- •Diagnosis other than idiopathic scoliosis
- •Poorly controlled seizures or the presence of a cochlear implant
- •Patient history or family history of malignant hypothermia or mitochondrial myopathies
研究组 & 干预措施
desflurane MEP's
Transcranial motor evoked potentials are obtained under total intravenous anesthesia (TIVA) and again after desflurane at 3%, for at least 5 minutes.at two different time points. Each subject is his/her own control
干预措施: Desflurane (Drug)
结局指标
主要结局
Effect of Pulse Train Length on Transcranial Motor Evoked Potentials (TcMEP) Area Under Total Intravenous Anesthesia (TIVA) and TIVA Plus 3% Desflurane
时间窗: 15 minutes
A series of 15 transcranial motor evoked potentials are recorded under a TIVA anesthetic and again after addition of 3% desflurane for 5 minutes at two different time points in a surgical procedure. The series consisted of 3 runs of 5,6, 7, 8, and 9 pulse trains, each train separated by 30 seconds. The 3 runs were averaged to give and average value of TcMEP amplitude and area for the 5,6,7,8 and 9 pulse trains. The data were used to compute regression coefficients for area vs pulse length for the TIVA case and TIVA plus desflurane for each participant who completed the study..The final measure is the number of participants who had a MEP area ratios significantly different from 1 at all times and conditions; that is for TIVA alone and TIVA plus desflurane, at both time points.
次要结局
未报告次要终点