Understanding the Psychological Benefits and Neurophysiological Mechanisms of Qigong in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Depressive symptoms
研究概览
简要总结
One goal of the study is to evaluate the efficacy of qigong to alleviate depressive symptoms and enhance cognitive function in comparison to mindfulness-based intervention, physical exercise, and waitlist control. The other goal is to explore the changes in neurobiological markers that may explain the qigong-related effects on depressive symptoms and cognitive function. The main research questions are:
- Is the 12-week qigong training more effective than mindfulness-based intervention, physical exercise, and waitlist control to alleviate depressive symptoms?
- Is the 12-week qigong training more effective than mindfulness-based intervention, physical exercise, and waitlist control to enhance cognitive function?
Participants are older adults aged 60 or above. They were randomly assigned to qigong training, mindfulness training, physical exercise training, or wait-list which all last for 12 weeks. Their changes before and after the 12-week period in depressive symptoms, neurobiological markers, and cognitive functions are assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •60 years or older;
- •With mild or severer levels of depressive symptoms as indicated by the Geriatric Depression Scale (GDS-8) scores of 5 or above, or Depression Anxiety and Stress Scale-21 (DASS-21) depression subscale scores of 4 or above
- •Self-identified as physically stable and without life-threatening diseases.
- •Be able to communicate in Cantonese or Mandarin.
排除标准
- •Have a history of practicing or receiving training of any form of mind-body or regular exercises (including tai chi, yoga, and qigong, or regular physical activity > 3 times/week) during the month prior to intervention
- •Have changed medications or the dose of medications prescribed for their health condition in the one month prior to study enrollment
- •Have severe cognitive or language impairment based on the assessment with Montreal Cognitive Assessment (MoCA)
- •Taking medication or undergoing electroconvulsive therapy, psychotherapy, or psychoeducation for a psychological or psychiatric condition
- •Unable to demonstrate satisfactory standing balance
研究组 & 干预措施
Qigong (Baduanjin)
12-week training of Baduanjin, with two sessions per week. Each session lasts for 60 min.
干预措施: Qigong (Baduanjin) (Behavioral)
Mindfulness-based intervention
12-week training of mindfulness-based breathing, walking, and stretching practices, with two sessions per week. Each session lasts for 60 min.
干预措施: Mindfulness-based intervention (Behavioral)
Physical exercise
12-week training of stretching, flexibility exercise, and balance exercise, with two sessions per week. Each session lasts for 60 min.
干预措施: Physical exercise (Behavioral)
Waitlist control
Participants of the waitlist control group will not receive any training while the other three group are having their interventions. After the completion of the all assessments, the participants will receive the 12-week qigong training, same as the qigong group.
结局指标
主要结局
Depressive symptoms
时间窗: Baseline and post-intervention (12 weeks after baseline)
The eight-item Patient Health Questionnaire
Global cognitive function
时间窗: Baseline and post-intervention (12 weeks after baseline)
Montreal Cognitive Assessment
次要结局
- Serum BDNF(Baseline and post-intervention (12 weeks after baseline))
- Serum adiponectin(Baseline and post-intervention (12 weeks after baseline))
- Salivary cortisol(Baseline and post-intervention (12 weeks after baseline))
- Attention(Baseline and post-intervention (12 weeks after baseline))
- Inhibitory control(Baseline and post-intervention (12 weeks after baseline))
- Working memory(Baseline and post-intervention (12 weeks after baseline))
- ERP N2 amplitude(Baseline and post-intervention (12 weeks after baseline))
- ERP P3 amplitude(Baseline and post-intervention (12 weeks after baseline))
- Hand grip strength(Baseline and post-intervention (12 weeks after baseline))
- Affect(Baseline and post-intervention (12 weeks after baseline))
研究者
TSANG Hector Wing-Hong
Professor
The Hong Kong Polytechnic University