The Effect of Sertraline In Treatment Of Schizophrenia
- Conditions
- schizophrenia.The schizophrenic disorders are characterized in general by fundamental and characteristic distortions of thinking and perception, and affects that are inappropriate or blunted. Clear consciousness and intellectual capacity are usually maintained although
- Registration Number
- IRCT2014041317246N1
- Lead Sponsor
- Vice Chancellor for Research and Technology Development-Ahwaz Jondishapur University of Medical Sci
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion criteria for this study are as follows: schizophrenia - a negative score more than 15 in PANSS; no liver disease; not treated with ECT in the past six months; during illness for over one year; aged between 21 to 63 years old.
The Exclusion criteria are: depression; mental retardation; schizoaffective disorder; bipolar disorder; a neurological disorder such as epilepsy, Parkinson's disease; a risky physical illness such as cardiac ischemia or heart failure; use of antidepressants or lithium for whatever reason; Leisure drug; drug abuse within one recent month (except nicotine and caffeine); extrapyramidal side effects; deafness or dumbness active suicidal or homicidal thoughts; pregnant or lactating women; at least 3 months have passed since the last time the use of long-acting antipsychotics; drugs with a history of hypersensitivity or serious interest in the study; the patient withdrew from the study and side effects.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Emotional withdrawal. Timepoint: Before intervention,1 week after intervention, 3 weeks after intervention, 6 weeks after intervention. Method of measurement: PANSS(Positive and Negative Symptom Scale).;Social withdrawal. Timepoint: Before intervention, 1 week after intervention, 3 weeks after intervention, 6 weeks after intervention. Method of measurement: PANSS(Positive and Negative Symptom Scale).;Blunted affect. Timepoint: Before intervention,1 week after intervention, 3 weeks after intervention, 6 weeks after intervention. Method of measurement: PANSS(Positive and Negative Symptom Scale).;Other negative symptoms. Timepoint: Before intervevtion, 1 week after intervention, 3 weeks after intervention, 6 weeks after intervention. Method of measurement: PANSS(Positive and Negative Symptom Scale).
- Secondary Outcome Measures
Name Time Method Side effects. Timepoint: One week after intervention,3 weeks after intervention,6 weeks after intervention. Method of measurement: Interview with patient.