Remote Post-Conditioning (RPC) in renal transplantatio

Completed

• Conditions: Kidney injury after transplantation; Urological and Genital Diseases; Surgical operation with transplant of whole organ

• Registration Number: ISRCTN66437627
• Lead Sponsor: niversity of Leicester (UK)

Brief Summary

2015 results in: https://www.ncbi.nlm.nih.gov/pubmed/26252316

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-09-19
• Study Completion: 2014-08-21
• Last Update Posted: 19 February 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Age greater than or equal to 18 years
2. Patients receiving a primary or secondary renal allograft from a live or donation after Brain Stem Death (DBD donor)
3. Patients with second transplants must have maintained their primary graft for at least six months after transplantation (with the exception of graft failure due to technical reasons)
4. Signed written informed consent

Exclusion Criteria

1. Blood type ABO incompatible live donor transplants
2. Donation after cardiac death donors
3. Patients with severe peripheral vascular disease
4. Patients on ATP-sensitive potassium channel opening or blocking drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ive donor:<br>1. Slow graft function measured by creatinine fall in the first 24 hours and Area under the curve (AUC) serum creatinine over the first 7 days post transplant <br>2. Graft function rates: incidences of delayed graft function and primary non-function<br>3. Glomerular filtration rate (eGFR) and serum creatinine levels: 1 and 3 months<br>4. Graft survival<br>5. Patient survival<br>6. Episodes of rejection within the first 3 months (cell and antibody mediated)<br><br>Deceased donor:<br>1. Slow graft function measured by creatinine fall in the first 24 hours and Area under the curve (AUC) serum creatinine over the first 7 days post transplant <br>2. Graft function; incidences of delayed graft function and primary non-function<br>3. Glomerular filtration rate (eGFR) and serum creatinine levels: 1 and 3 months<br>4. Graft survival<br>5. Patient survival<br>6. Episodes of rejection within the first 3 months (cell and antibody mediated)