Chronic Arterial Disease, Quality of Life and Mortality in Chronic Kidney Injury
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Kidney Diseases
- Sponsor
- Turku University Hospital
- Enrollment
- 210
- Locations
- 1
- Primary Endpoint
- Mortality
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
CADKID-study is a prospective follow-up study assessing arterial disease, quality of life, mortality and their predictors in patients with severe chronic kidney disease.
Detailed Description
Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease and mortality as well as impaired quality of life. Participants of this study all have severe CKD, defined as estimated glomerular filtration rate \< 30 ml/min per 1.73 m\^2. Stress ergometry, echocardiography, ultrasound assessment of arterial intima-media thickness, lateral lumbar radiograph, ECG, laboratory tests and quality of life assessment were performed at the baseline of the study and will be repeated during follow-up. Atrial fibrillation and other cardiac arrhythmias as well as pulse wave velocity measurements will be explored. Diet diaries are gathered and analysed. The aim of the study is to identify factors associated with cardiovascular disease, quality of life and mortality in this cohort.
Investigators
Eligibility Criteria
Inclusion Criteria
- •estimated glomerular filtration rate \< 30 ml/min per 1.73 m\^2
Exclusion Criteria
- •age under 18 years
- •inability to give informed consent
Outcomes
Primary Outcomes
Mortality
Time Frame: 5 years
Cardiovascular morbidity
Time Frame: 5 years
Secondary Outcomes
- Changes in quality of life(2 years, 5 years)
- Rate of hospitalizations(2 years, 5 years)
- Carotid intima-media thickness(2 years, 5 years)
- Maximal bicycle stress ergometry performance(2 years, 5 years)
- Femoral intima-media thickness(2 years, 5 years)
- Flow-mediated dilatation of brachial artery(2 years, 5 years)
- Cardiac diastolic function(2 years, 5 years)
- Number of participants with cardiac arrhythmias(2 years, 5 years)
- Abdominal aortic calcification (AAC) score(2 years, 5 years)
- Left ventricular hypertrophy(2 years, 5 years)
- Cardiac systolic function(2 years, 5 years)