Chronic Arterial Disease, Quality of Life and Mortality in Chronic Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
CADKID-study is a prospective follow-up study assessing arterial disease, quality of life, mortality and their predictors in patients with severe chronic kidney disease.
详细描述
Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease and mortality as well as impaired quality of life. Participants of this study all have severe CKD, defined as estimated glomerular filtration rate < 30 ml/min per 1.73 m^2. Stress ergometry, echocardiography, ultrasound assessment of arterial intima-media thickness, lateral lumbar radiograph, ECG, laboratory tests and quality of life assessment were performed at the baseline of the study and will be repeated during follow-up. Atrial fibrillation and other cardiac arrhythmias as well as pulse wave velocity measurements will be explored. Diet diaries are gathered and analysed. The aim of the study is to identify factors associated with cardiovascular disease, quality of life and mortality in this cohort.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •estimated glomerular filtration rate < 30 ml/min per 1.73 m^2
排除标准
- •age under 18 years
- •inability to give informed consent
结局指标
主要结局
Mortality
时间窗: 5 years
Cardiovascular morbidity
时间窗: 5 years
次要结局
- Changes in quality of life(2 years, 5 years)
- Rate of hospitalizations(2 years, 5 years)
- Carotid intima-media thickness(2 years, 5 years)
- Maximal bicycle stress ergometry performance(2 years, 5 years)
- Femoral intima-media thickness(2 years, 5 years)
- Flow-mediated dilatation of brachial artery(2 years, 5 years)
- Cardiac diastolic function(2 years, 5 years)
- Number of participants with cardiac arrhythmias(2 years, 5 years)
- Abdominal aortic calcification (AAC) score(2 years, 5 years)
- Left ventricular hypertrophy(2 years, 5 years)
- Cardiac systolic function(2 years, 5 years)